Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro

Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro

Arsenic is a neurotoxin associated with cognitive impairment following long-term exposure, while Neurotrophin-3 (NT-3) is essential for the survival and development of neurons. This study aims to explore the protective effects of NT-3 on arsenic-caused cognitive impairment and neuronal damage, as we...

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Bibliographic Details
Main Authors: Jia Cui, Ziqiao Guan, Xinbo Ma, Xinhua Shao, Kunyu Zhang, Man Lv, Meichen Zhang, Xiaona Liu, Yanhui Gao, Yanmei Yang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Arsenic
Hippocampal neuron
Apoptosis
NT-3
PI3K/AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325007080
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