Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)
Chimeric antigen receptor (CAR) T cells represent one of the newest frontiers of cell therapy. Their application currently involves relapsed/refractory aggressive B cell lymphoma and leukemia as a standard of care, while several studies are exploring CAR-T to treat multiple myeloma and other hematol...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-10-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://mjhid.org/index.php/mjhid/article/view/4745 |
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| _version_ | 1850060619444649984 |
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| author | Eugenio Galli Silvia Bellesi Marcello Viscovo Federica Sorà Stefan Hohaus Nicola Piccirillo Luca Laurenti Patrizia Chiusolo Valerio De Stefano Simona Sica Gina Zini |
| author_facet | Eugenio Galli Silvia Bellesi Marcello Viscovo Federica Sorà Stefan Hohaus Nicola Piccirillo Luca Laurenti Patrizia Chiusolo Valerio De Stefano Simona Sica Gina Zini |
| author_sort | Eugenio Galli |
| collection | DOAJ |
| description | Chimeric antigen receptor (CAR) T cells represent one of the newest frontiers of cell therapy. Their application currently involves relapsed/refractory aggressive B cell lymphoma and leukemia as a standard of care, while several studies are exploring CAR-T to treat multiple myeloma and other hematological malignancies. Here we describe the cytomorphology of CAR-T collected from the leftovers of infusion bags, and therefore before the encounter with the antigen, with, among others, a peculiar population of giant lymphoid cells with blastoid features and hypertrophic centrosome. |
| format | Article |
| id | doaj-art-493f5cb3a717421b91f2de8c1a069caa |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-493f5cb3a717421b91f2de8c1a069caa2025-08-20T02:50:30ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062021-10-0113110.4084/MJHID.2021.066Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)Eugenio Galli0Silvia BellesiMarcello ViscovoFederica SoràStefan HohausNicola PiccirilloLuca LaurentiPatrizia ChiusoloValerio De StefanoSimona SicaGina ZiniCatholic University of Sacred HeartChimeric antigen receptor (CAR) T cells represent one of the newest frontiers of cell therapy. Their application currently involves relapsed/refractory aggressive B cell lymphoma and leukemia as a standard of care, while several studies are exploring CAR-T to treat multiple myeloma and other hematological malignancies. Here we describe the cytomorphology of CAR-T collected from the leftovers of infusion bags, and therefore before the encounter with the antigen, with, among others, a peculiar population of giant lymphoid cells with blastoid features and hypertrophic centrosome.http://mjhid.org/index.php/mjhid/article/view/4745Chimeric antigen receptor T cellsCAR-Tcytomorphologyimmunotherapycell therapy |
| spellingShingle | Eugenio Galli Silvia Bellesi Marcello Viscovo Federica Sorà Stefan Hohaus Nicola Piccirillo Luca Laurenti Patrizia Chiusolo Valerio De Stefano Simona Sica Gina Zini Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) Mediterranean Journal of Hematology and Infectious Diseases Chimeric antigen receptor T cells CAR-T cytomorphology immunotherapy cell therapy |
| title | Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) |
| title_full | Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) |
| title_fullStr | Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) |
| title_full_unstemmed | Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) |
| title_short | Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T) |
| title_sort | cytomorphology of chimeric antigen receptor t cells car t |
| topic | Chimeric antigen receptor T cells CAR-T cytomorphology immunotherapy cell therapy |
| url | http://mjhid.org/index.php/mjhid/article/view/4745 |
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