Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives
Present study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents and N-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucid...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/161783 |
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| author | Rajiv Dahiya Anil Kumar |
| author_facet | Rajiv Dahiya Anil Kumar |
| author_sort | Rajiv Dahiya |
| collection | DOAJ |
| description | Present study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents and N-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucidation of all the newly synthesized compounds was done by elemental analysis and IR, 1H NMR, 13C NMR and mass spectral data. Synthesized imidazolopeptides were screened for their anthelmintic activity and found to possess moderate to good bioactivity against earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniea when compared to reference drugs - albendazole and mebendazole at dose level of 2 mg mL−1. |
| format | Article |
| id | doaj-art-4928a4ce66ec40248bce9dedbd428c95 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-4928a4ce66ec40248bce9dedbd428c952025-02-03T01:01:18ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015S21133114310.1155/2008/161783Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole DerivativesRajiv Dahiya0Anil Kumar1Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh-281 001, IndiaDepartment of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh-281 001, IndiaPresent study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents and N-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucidation of all the newly synthesized compounds was done by elemental analysis and IR, 1H NMR, 13C NMR and mass spectral data. Synthesized imidazolopeptides were screened for their anthelmintic activity and found to possess moderate to good bioactivity against earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniea when compared to reference drugs - albendazole and mebendazole at dose level of 2 mg mL−1.http://dx.doi.org/10.1155/2008/161783 |
| spellingShingle | Rajiv Dahiya Anil Kumar Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives E-Journal of Chemistry |
| title | Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives |
| title_full | Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives |
| title_fullStr | Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives |
| title_full_unstemmed | Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives |
| title_short | Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives |
| title_sort | synthesis spectral and anthelmintic activity studies on some novel imidazole derivatives |
| url | http://dx.doi.org/10.1155/2008/161783 |
| work_keys_str_mv | AT rajivdahiya synthesisspectralandanthelminticactivitystudiesonsomenovelimidazolederivatives AT anilkumar synthesisspectralandanthelminticactivitystudiesonsomenovelimidazolederivatives |