UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus
Polyacrylamide (PAA) hydrogels have become a widely used tool whose easily tunable mechanical properties, biocompatibility, thermostability, and chemical inertness make them invaluable in many biological applications, such as cell mechanosensitivity studies. Currently, preparation of PAA gels involv...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2017/5147482 |
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| _version_ | 1832564186770571264 |
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| author | Saahil Sheth Era Jain Amin Karadaghy Sana Syed Hunter Stevenson Silviya P. Zustiak |
| author_facet | Saahil Sheth Era Jain Amin Karadaghy Sana Syed Hunter Stevenson Silviya P. Zustiak |
| author_sort | Saahil Sheth |
| collection | DOAJ |
| description | Polyacrylamide (PAA) hydrogels have become a widely used tool whose easily tunable mechanical properties, biocompatibility, thermostability, and chemical inertness make them invaluable in many biological applications, such as cell mechanosensitivity studies. Currently, preparation of PAA gels involves mixtures of acrylamide, bisacrylamide, a source of free radicals, and a chemical stabilizer. This method, while generally well accepted, has its drawbacks: long polymerization times, unstable and toxic reagents, and tedious preparation. Alternatively, PAA gels could be made by free radical polymerization (FRP) using ultraviolet (UV) photopolymerization, a method which is quicker, less tedious, and less toxic. Here, we describe a simple strategy based on total UV energy for determining the optimal UV crosslinking conditions that lead to optimal hydrogel modulus. |
| format | Article |
| id | doaj-art-49202e9c2324479d8e366105fd784ffd |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-49202e9c2324479d8e366105fd784ffd2025-02-03T01:11:34ZengWileyInternational Journal of Polymer Science1687-94221687-94302017-01-01201710.1155/2017/51474825147482UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel ModulusSaahil Sheth0Era Jain1Amin Karadaghy2Sana Syed3Hunter Stevenson4Silviya P. Zustiak5Department of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USADepartment of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USADepartment of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USADepartment of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USADepartment of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USADepartment of Biomedical Engineering, Parks College of Engineering, Aviation and Technology, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO 63103, USAPolyacrylamide (PAA) hydrogels have become a widely used tool whose easily tunable mechanical properties, biocompatibility, thermostability, and chemical inertness make them invaluable in many biological applications, such as cell mechanosensitivity studies. Currently, preparation of PAA gels involves mixtures of acrylamide, bisacrylamide, a source of free radicals, and a chemical stabilizer. This method, while generally well accepted, has its drawbacks: long polymerization times, unstable and toxic reagents, and tedious preparation. Alternatively, PAA gels could be made by free radical polymerization (FRP) using ultraviolet (UV) photopolymerization, a method which is quicker, less tedious, and less toxic. Here, we describe a simple strategy based on total UV energy for determining the optimal UV crosslinking conditions that lead to optimal hydrogel modulus.http://dx.doi.org/10.1155/2017/5147482 |
| spellingShingle | Saahil Sheth Era Jain Amin Karadaghy Sana Syed Hunter Stevenson Silviya P. Zustiak UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus International Journal of Polymer Science |
| title | UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus |
| title_full | UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus |
| title_fullStr | UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus |
| title_full_unstemmed | UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus |
| title_short | UV Dose Governs UV-Polymerized Polyacrylamide Hydrogel Modulus |
| title_sort | uv dose governs uv polymerized polyacrylamide hydrogel modulus |
| url | http://dx.doi.org/10.1155/2017/5147482 |
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