Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis
Objective. To investigate the diagnostic value of interferon-gamma release assays combined with multiple indicators for tuberculous peritonitis. Methods. Patients who were admitted to the hospital due to suspected tuberculous peritonitis were prospectively included during the 30-month study period....
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/2056168 |
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| author | Xidong He Yuanxue Gao Qi Liu Zhifang Zhao Wanhang Deng Hong Yang |
| author_facet | Xidong He Yuanxue Gao Qi Liu Zhifang Zhao Wanhang Deng Hong Yang |
| author_sort | Xidong He |
| collection | DOAJ |
| description | Objective. To investigate the diagnostic value of interferon-gamma release assays combined with multiple indicators for tuberculous peritonitis. Methods. Patients who were admitted to the hospital due to suspected tuberculous peritonitis were prospectively included during the 30-month study period. Moreover, healthy individuals were recruited and included in the control group. All the study participants were assessed using various indexes, such as interferon-gamma release assays. Results. A total of 180 patients with suspected tuberculous peritonitis were enrolled, and 24 were excluded. 73 patients with a confirmed diagnosis of tuberculous peritonitis were included in the tuberculous peritonitis group, 83 patients with other diseases in the other-disease control group, and 52 healthy individuals in the control group. Moreover, 83 patients in the other-disease control group and 52 participants in the control group were identified as 135 nontuberculous peritonitis patients. The area under the receiver operating characteristics curve for the QuantiFERON-TB test was 0.851 (95% confidence interval: 0.799–0.903), and the optimal cutoff value was 0.55 IU/mL, which corresponds to a sensitivity and specificity of 86.30% and 80.00%, respectively. The receiver operating characteristic curves for the combination of the QuantiFERON-TB test and the use of erythrocyte sedimentation rate, serum adenosine deaminase level, serum cancer antigen 125 level, and hypersensitive C-reactive protein level had an area under the curve of 0.859 (95% confidence interval: 0.809–0.909), with a sensitivity and specificity of 97.26% and 62.96%, respectively. Conclusions. The combined use of the QuantiFERON-TB test and multiple indexes can significantly improve the accuracy of diagnosing tuberculous peritonitis. |
| format | Article |
| id | doaj-art-490299f4e93a47189918b13194b86caa |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-490299f4e93a47189918b13194b86caa2025-02-03T00:58:41ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/20561682056168Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous PeritonitisXidong He0Yuanxue Gao1Qi Liu2Zhifang Zhao3Wanhang Deng4Hong Yang5Department of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Gastroenterology, Guizhou Provincial People’s Hospital, Guiyang 550002, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaObjective. To investigate the diagnostic value of interferon-gamma release assays combined with multiple indicators for tuberculous peritonitis. Methods. Patients who were admitted to the hospital due to suspected tuberculous peritonitis were prospectively included during the 30-month study period. Moreover, healthy individuals were recruited and included in the control group. All the study participants were assessed using various indexes, such as interferon-gamma release assays. Results. A total of 180 patients with suspected tuberculous peritonitis were enrolled, and 24 were excluded. 73 patients with a confirmed diagnosis of tuberculous peritonitis were included in the tuberculous peritonitis group, 83 patients with other diseases in the other-disease control group, and 52 healthy individuals in the control group. Moreover, 83 patients in the other-disease control group and 52 participants in the control group were identified as 135 nontuberculous peritonitis patients. The area under the receiver operating characteristics curve for the QuantiFERON-TB test was 0.851 (95% confidence interval: 0.799–0.903), and the optimal cutoff value was 0.55 IU/mL, which corresponds to a sensitivity and specificity of 86.30% and 80.00%, respectively. The receiver operating characteristic curves for the combination of the QuantiFERON-TB test and the use of erythrocyte sedimentation rate, serum adenosine deaminase level, serum cancer antigen 125 level, and hypersensitive C-reactive protein level had an area under the curve of 0.859 (95% confidence interval: 0.809–0.909), with a sensitivity and specificity of 97.26% and 62.96%, respectively. Conclusions. The combined use of the QuantiFERON-TB test and multiple indexes can significantly improve the accuracy of diagnosing tuberculous peritonitis.http://dx.doi.org/10.1155/2020/2056168 |
| spellingShingle | Xidong He Yuanxue Gao Qi Liu Zhifang Zhao Wanhang Deng Hong Yang Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis Gastroenterology Research and Practice |
| title | Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis |
| title_full | Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis |
| title_fullStr | Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis |
| title_full_unstemmed | Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis |
| title_short | Diagnostic Value of Interferon-Gamma Release Assays Combined with Multiple Indicators for Tuberculous Peritonitis |
| title_sort | diagnostic value of interferon gamma release assays combined with multiple indicators for tuberculous peritonitis |
| url | http://dx.doi.org/10.1155/2020/2056168 |
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