TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B

TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B

Abstract Clostridioides difficile, a spore-forming anaerobic bacterium, is the primary cause of hospital antibiotic-associated diarrhea. Key virulence factors, toxins A (TcdA) and B (TcdB), significantly contribute to C. difficile infection (CDI). Yet, the specific impact of these toxins, particular...

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Main Authors: Dvison de Melo Pacífico, Deiziane Viana da Silva Costa, Maria Lucianny Lima Barbosa, Conceição Silva Martins Rebouças, Simone de Goes Simonato, Cirle Alcantara Warren, Maria Luana Gaudencio dos Santos Morais, Renata Ferreira de Carvalho Leitao, Gerly Anne de Castro Brito
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Inflammation
Subjects:
C. difficile
Enteric glia
TRPV4
Inflammation
Cell death
Online Access:https://doi.org/10.1186/s12950-024-00425-7
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