A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great a...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7247238 |
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| _version_ | 1832558445346160640 |
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| author | Qingdong Guan |
| author_facet | Qingdong Guan |
| author_sort | Qingdong Guan |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies. |
| format | Article |
| id | doaj-art-48ed05e23db546eaa9c1794e1eebfd19 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-48ed05e23db546eaa9c1794e1eebfd192025-02-03T01:32:17ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/72472387247238A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel DiseaseQingdong Guan0Department of Immunology, University of Manitoba, Manitoba, CanadaInflammatory bowel disease (IBD) is a chronic and life-threating inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis of IBD is complex. Recent studies have greatly improved our knowledge of the pathophysiology of IBD, leading to great advances in the treatment as well as diagnosis of IBD. In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.http://dx.doi.org/10.1155/2019/7247238 |
| spellingShingle | Qingdong Guan A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease Journal of Immunology Research |
| title | A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease |
| title_full | A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease |
| title_fullStr | A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease |
| title_full_unstemmed | A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease |
| title_short | A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease |
| title_sort | comprehensive review and update on the pathogenesis of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2019/7247238 |
| work_keys_str_mv | AT qingdongguan acomprehensivereviewandupdateonthepathogenesisofinflammatoryboweldisease AT qingdongguan comprehensivereviewandupdateonthepathogenesisofinflammatoryboweldisease |