Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells

Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells

Abstract Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide, and few effective therapeutics are available. Osthole (OST), a natural coumarin, has been proven to be a potential anticancer compound. In this study, we found that OST significantly inhibited PC growth both in vit...

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Bibliographic Details
Main Authors: Ningna Weng, Sujuan Lv, Hong Chen, Hanchen Zheng, Tong Lin, Qing Zhu, Kai Zhu, Sha Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Osthole
Pancreatic cancer
Autophagy
ATF3
mTOR
Online Access:https://doi.org/10.1038/s41598-024-81911-z
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