Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report
Disseminated Intravascular Coagulopathy (DIC) is the most common coagulopathy in patients with prostate cancer. Though rare, it could be fatal without treatment. Literature suggests that there is significant activation of fibrinolytic pathway. Pathophysiology of DIC in patients with prostate cancer...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.143 |
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| _version_ | 1832558792874655744 |
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| author | Keisuke Shirai Uzair B. Chaudhary |
| author_facet | Keisuke Shirai Uzair B. Chaudhary |
| author_sort | Keisuke Shirai |
| collection | DOAJ |
| description | Disseminated Intravascular Coagulopathy (DIC) is the most common coagulopathy in patients with prostate cancer. Though rare, it could be fatal without treatment. Literature suggests that there is significant activation of fibrinolytic pathway. Pathophysiology of DIC in patients with prostate cancer is not completely understood. We present here a case of chronic DIC in a patient with metastatic androgen independent prostate cancer. His DIC was managed successfully with a combination of aminocaproic acid and low weight molecular heparin. The use of low molecular weight heparin may make management of chronic DIC in prostate cancer more feasible in an out patient setting. |
| format | Article |
| id | doaj-art-48d281b587404c869a2b061b5e017276 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-48d281b587404c869a2b061b5e0172762025-02-03T01:31:35ZengWileyThe Scientific World Journal1537-744X2007-01-01775375510.1100/tsw.2007.143Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case ReportKeisuke Shirai0Uzair B. Chaudhary1Department of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USADepartment of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USADisseminated Intravascular Coagulopathy (DIC) is the most common coagulopathy in patients with prostate cancer. Though rare, it could be fatal without treatment. Literature suggests that there is significant activation of fibrinolytic pathway. Pathophysiology of DIC in patients with prostate cancer is not completely understood. We present here a case of chronic DIC in a patient with metastatic androgen independent prostate cancer. His DIC was managed successfully with a combination of aminocaproic acid and low weight molecular heparin. The use of low molecular weight heparin may make management of chronic DIC in prostate cancer more feasible in an out patient setting.http://dx.doi.org/10.1100/tsw.2007.143 |
| spellingShingle | Keisuke Shirai Uzair B. Chaudhary Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report The Scientific World Journal |
| title | Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report |
| title_full | Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report |
| title_fullStr | Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report |
| title_full_unstemmed | Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report |
| title_short | Use of Low Molecular Weight Heparin and Aminocaproic Acid in Chronic DIC Associated with Prostate Cancer- A Case Report |
| title_sort | use of low molecular weight heparin and aminocaproic acid in chronic dic associated with prostate cancer a case report |
| url | http://dx.doi.org/10.1100/tsw.2007.143 |
| work_keys_str_mv | AT keisukeshirai useoflowmolecularweightheparinandaminocaproicacidinchronicdicassociatedwithprostatecanceracasereport AT uzairbchaudhary useoflowmolecularweightheparinandaminocaproicacidinchronicdicassociatedwithprostatecanceracasereport |