PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress

PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress

Abstract Background Visceral pain sensitization and emotional reactions due to irritable bowel syndrome (IBS) occur frequently in the general population. Oxidative stress plays a crucial role in the pathogenesis of IBS. Previous studies have demonstrated that activation of peroxisome proliferator-ac...

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Bibliographic Details
Main Authors: Minjie Li, Xiyu Zhuo, Yongxiao Liu, Jinchao You, Jianqing Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Gastroenterology
Subjects:
Irritable bowel syndrome
Visceral pain sensitivity
Anxiety
PPARγ
Oxidative stress
Online Access:https://doi.org/10.1186/s12876-025-03618-3
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