The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways

The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways

Endosomal toll-like receptors (TLRs) TLR7, TLR8, and TLR9 play an important role in systemic lupus erythematosus (SLE) pathogenesis. The proteolytic processing of these receptors in the endolysosome is required for signaling in response to DNA and single-stranded RNA, respectively. Targeting this pr...

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Bibliographic Details
Main Authors: Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
systemic lupus erythematosus (SLE)
inflammation
toll-like receptors (TLRs)
human alpha-1 antitrypsin (hAAT)
Online Access:https://www.mdpi.com/2218-273X/15/1/43
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