Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab
Drug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous hemorrhage of the g...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2020/8818905 |
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| _version_ | 1832546869677391872 |
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| author | Lauren Klute Matthew Solverson Christopher M. Bingcang Jayme R. Dowdall |
| author_facet | Lauren Klute Matthew Solverson Christopher M. Bingcang Jayme R. Dowdall |
| author_sort | Lauren Klute |
| collection | DOAJ |
| description | Drug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous hemorrhage of the gingiva, there have not been reports of laryngeal hemorrhage with trastuzumab emtansine treatment. In this case report, we suggest that trastuzumab emtansine played a contributory role in the development of diffuse epithelial laryngeal hemorrhage and describe the pathophysiology, history, laryngoscopic findings, and management of this condition. |
| format | Article |
| id | doaj-art-48c1920bbc3040fd9ce3b0b403e27c32 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-48c1920bbc3040fd9ce3b0b403e27c322025-02-03T06:46:53ZengWileyCase Reports in Otolaryngology2090-67652090-67732020-01-01202010.1155/2020/88189058818905Diffuse Spontaneous Laryngeal Hemorrhage with TrastuzumabLauren Klute0Matthew Solverson1Christopher M. Bingcang2Jayme R. Dowdall3University of Nebraska Medical Center, Department of Otolaryngology-Head and Neck Surgery, 981225 Nebraska Medical Center, Omaha, Nebraska 68198-1225, USAUniversity of Nebraska Medical Center, Department of Otolaryngology-Head and Neck Surgery, 981225 Nebraska Medical Center, Omaha, Nebraska 68198-1225, USAUniversity of Nebraska Medical Center, Department of Otolaryngology-Head and Neck Surgery, 981225 Nebraska Medical Center, Omaha, Nebraska 68198-1225, USAUniversity of Nebraska Medical Center, Department of Otolaryngology-Head and Neck Surgery, 981225 Nebraska Medical Center, Omaha, Nebraska 68198-1225, USADrug-induced epithelial hemorrhage of the endolarynx is an unusual etiology of hemoptysis. We present a case of hemoptysis in a young female patient undergoing treatment for metastatic breast cancer with trastuzumab emtansine. Though previously associated with diffuse spontaneous hemorrhage of the gingiva, there have not been reports of laryngeal hemorrhage with trastuzumab emtansine treatment. In this case report, we suggest that trastuzumab emtansine played a contributory role in the development of diffuse epithelial laryngeal hemorrhage and describe the pathophysiology, history, laryngoscopic findings, and management of this condition.http://dx.doi.org/10.1155/2020/8818905 |
| spellingShingle | Lauren Klute Matthew Solverson Christopher M. Bingcang Jayme R. Dowdall Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab Case Reports in Otolaryngology |
| title | Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab |
| title_full | Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab |
| title_fullStr | Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab |
| title_full_unstemmed | Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab |
| title_short | Diffuse Spontaneous Laryngeal Hemorrhage with Trastuzumab |
| title_sort | diffuse spontaneous laryngeal hemorrhage with trastuzumab |
| url | http://dx.doi.org/10.1155/2020/8818905 |
| work_keys_str_mv | AT laurenklute diffusespontaneouslaryngealhemorrhagewithtrastuzumab AT matthewsolverson diffusespontaneouslaryngealhemorrhagewithtrastuzumab AT christophermbingcang diffusespontaneouslaryngealhemorrhagewithtrastuzumab AT jaymerdowdall diffusespontaneouslaryngealhemorrhagewithtrastuzumab |