Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017)
ABSTRACT Introduction An uncommon and diverse class of cancers originating from mesenchymal tissues is designated as soft tissue sarcoma (STS). To develop effective preventive and treatment strategies for STS, it is essential to gain a deeper understanding of the epidemiological trends associated wi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70118 |
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| author | Mohammad Sajed Dehghan Banadaki Vahid Rahmanian Saeed Hosseini Seyyed Mohammad Hossein Hosseini Narjes Hazar |
| author_facet | Mohammad Sajed Dehghan Banadaki Vahid Rahmanian Saeed Hosseini Seyyed Mohammad Hossein Hosseini Narjes Hazar |
| author_sort | Mohammad Sajed Dehghan Banadaki |
| collection | DOAJ |
| description | ABSTRACT Introduction An uncommon and diverse class of cancers originating from mesenchymal tissues is designated as soft tissue sarcoma (STS). To develop effective preventive and treatment strategies for STS, it is essential to gain a deeper understanding of the epidemiological trends associated with the disease. This research will analyze the 4‐year age‐standardized incidence rate (ASIR) and geographical distribution of STS in Iran in great detail. Methods The study population comprised 4968 cases of STS recorded in the Cancer Registry System between 2014 and 2017. The demographic data examined included gender, place of residence, and year of diagnosis. The age‐standardized rate (ASR) of STS incidence was calculated for each location using the World Standard Population. The data were examined using the program ArcMap10.5. The geographic distribution of STS was investigated using the Moran test. Results The ASRs for STS in Iran from 2014 to 2017 were recorded as 1.25 (ASR in male: 1.47, ASR in female: 1.06), 1.36 (ASR in male: 1.46, ASR in female: 1.29), 1.37 (ASR in male: 1.52, ASR in female: 1.21), and 1.78 (ASR in male: 1.58, ASR in female: 1.98), respectively. In 2014 and 2015, age‐standardized incidence at the national level showed a statistically significant regional dispersion that appeared as a clustering pattern, according to Moran's test. However, in 2016 and 2017, this dispersion failed to become statistically significant. Interestingly, men had a greater rate of STS incidence than females. As age grows, ASIR shows a steadily rising trend. The most important gains are shown in the 55–59 age group, which peaked at 4.535 in 2017, and the 80–84 age group, which peaked at 10.848 in the same year. Conclusion The incidence of STS in Iran is lower than the global average. The discrepancies in gender disparities, regional distribution, and incidence rates underscore the complexity of STSs. The findings of this study may assist healthcare professionals and policymakers in the development of region‐specific plans for the treatment, early detection, and prevention of STSs. |
| format | Article |
| id | doaj-art-48c08c70dfb34e4d9f0ce684b57d2e6a |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Cancer Reports |
| spelling | doaj-art-48c08c70dfb34e4d9f0ce684b57d2e6a2025-01-30T15:46:35ZengWileyCancer Reports2573-83482025-01-0181n/an/a10.1002/cnr2.70118Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017)Mohammad Sajed Dehghan Banadaki0Vahid Rahmanian1Saeed Hosseini2Seyyed Mohammad Hossein Hosseini3Narjes Hazar4MD, School of Medicine Shahid Sadoughi University of Medical Sciences Yazd IranAssistant Professor in Epidemiology, Department of Public Health Torbat Jam Faculty of Medical Sciences Torbat Jam IranPh.D. Candidate in Epidemiology, Center for Healthcare Data Modeling, Department of Biostatistics and Epidemiology, School of Public Health Shahid Sadoughi University of Medical Sciences Yazd IranMSC in Epidemiology, Department of Biostatistics and Epidemiology Shahid Sadoughi University of Medical Sciences Yazd IranMD, Assistant Professor in Community Medicine, Diabetes Research Center Shahid Sadoughi University of Medical Sciences Yazd IranABSTRACT Introduction An uncommon and diverse class of cancers originating from mesenchymal tissues is designated as soft tissue sarcoma (STS). To develop effective preventive and treatment strategies for STS, it is essential to gain a deeper understanding of the epidemiological trends associated with the disease. This research will analyze the 4‐year age‐standardized incidence rate (ASIR) and geographical distribution of STS in Iran in great detail. Methods The study population comprised 4968 cases of STS recorded in the Cancer Registry System between 2014 and 2017. The demographic data examined included gender, place of residence, and year of diagnosis. The age‐standardized rate (ASR) of STS incidence was calculated for each location using the World Standard Population. The data were examined using the program ArcMap10.5. The geographic distribution of STS was investigated using the Moran test. Results The ASRs for STS in Iran from 2014 to 2017 were recorded as 1.25 (ASR in male: 1.47, ASR in female: 1.06), 1.36 (ASR in male: 1.46, ASR in female: 1.29), 1.37 (ASR in male: 1.52, ASR in female: 1.21), and 1.78 (ASR in male: 1.58, ASR in female: 1.98), respectively. In 2014 and 2015, age‐standardized incidence at the national level showed a statistically significant regional dispersion that appeared as a clustering pattern, according to Moran's test. However, in 2016 and 2017, this dispersion failed to become statistically significant. Interestingly, men had a greater rate of STS incidence than females. As age grows, ASIR shows a steadily rising trend. The most important gains are shown in the 55–59 age group, which peaked at 4.535 in 2017, and the 80–84 age group, which peaked at 10.848 in the same year. Conclusion The incidence of STS in Iran is lower than the global average. The discrepancies in gender disparities, regional distribution, and incidence rates underscore the complexity of STSs. The findings of this study may assist healthcare professionals and policymakers in the development of region‐specific plans for the treatment, early detection, and prevention of STSs.https://doi.org/10.1002/cnr2.70118epidemiologyincidence rateIransoft tissue sarcoma |
| spellingShingle | Mohammad Sajed Dehghan Banadaki Vahid Rahmanian Saeed Hosseini Seyyed Mohammad Hossein Hosseini Narjes Hazar Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) Cancer Reports epidemiology incidence rate Iran soft tissue sarcoma |
| title | Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) |
| title_full | Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) |
| title_fullStr | Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) |
| title_full_unstemmed | Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) |
| title_short | Epidemiology of Soft Tissue Sarcoma in Iran: Four‐Year National Cancer Registry Data Report (2014–2017) |
| title_sort | epidemiology of soft tissue sarcoma in iran four year national cancer registry data report 2014 2017 |
| topic | epidemiology incidence rate Iran soft tissue sarcoma |
| url | https://doi.org/10.1002/cnr2.70118 |
| work_keys_str_mv | AT mohammadsajeddehghanbanadaki epidemiologyofsofttissuesarcomainiranfouryearnationalcancerregistrydatareport20142017 AT vahidrahmanian epidemiologyofsofttissuesarcomainiranfouryearnationalcancerregistrydatareport20142017 AT saeedhosseini epidemiologyofsofttissuesarcomainiranfouryearnationalcancerregistrydatareport20142017 AT seyyedmohammadhosseinhosseini epidemiologyofsofttissuesarcomainiranfouryearnationalcancerregistrydatareport20142017 AT narjeshazar epidemiologyofsofttissuesarcomainiranfouryearnationalcancerregistrydatareport20142017 |