A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas
The Interferometric Reflectance Imaging Sensor (IRIS) technology represents a significant advancement in biosensing, providing a label-free, selective, sensitive, and high-throughput platform for detecting molecular interactions. This review explores the underlying principles, instrumentation, and d...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Biosensors and Bioelectronics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590137025000019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591764123287552 |
|---|---|
| author | Monireh Bakhshpour-Yucel Nese Lortlar Unlu Elif Seymour Adil Denizli |
| author_facet | Monireh Bakhshpour-Yucel Nese Lortlar Unlu Elif Seymour Adil Denizli |
| author_sort | Monireh Bakhshpour-Yucel |
| collection | DOAJ |
| description | The Interferometric Reflectance Imaging Sensor (IRIS) technology represents a significant advancement in biosensing, providing a label-free, selective, sensitive, and high-throughput platform for detecting molecular interactions. This review explores the underlying principles, instrumentation, and diverse applications of IRIS, with a focus on its efficacy for real-time monitoring of DNA-protein and protein-protein interactions, as well as virus detection. IRIS can measure DNA hybridization kinetics and identify pathogens without labeling, highlighting its versatility and reliability in biomedical research and diagnostics. IRIS achieves enhanced sensitivity and specificity by leveraging spectral reflectivity as a transduction mechanism and employing a 3D polymeric surface chemistry for bioreceptor immobilization. The review underscores IRIS's potential to revolutionize clinical diagnostics, biomolecular screening, and the study of biomolecular binding affinities, establishing it as a powerful tool for future research and medical applications. |
| format | Article |
| id | doaj-art-48ba67d3251a4feaac4b777dffdbc831 |
| institution | Kabale University |
| issn | 2590-1370 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosensors and Bioelectronics: X |
| spelling | doaj-art-48ba67d3251a4feaac4b777dffdbc8312025-01-22T05:43:56ZengElsevierBiosensors and Bioelectronics: X2590-13702025-03-0122100574A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areasMonireh Bakhshpour-Yucel0Nese Lortlar Unlu1Elif Seymour2Adil Denizli3Department of Chemistry, Faculty of Arts and Science, Bursa Uludag University, 16059, Bursa, Turkiye; Corresponding author. Bursa Uludag University, Department of Chemistry, Faculty of Arts and Science, Bursa, Turkiye.Faculty of Medicine, Histology and Embryology, Atlas University, 34408, İstanbul, Turkiye; Photonics Center, Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USABoston University Business Incubation Center, Boston, MA, 02215, USADepartment of Chemistry, Faculty of Science, Hacettepe University, 06800, Ankara, TurkiyeThe Interferometric Reflectance Imaging Sensor (IRIS) technology represents a significant advancement in biosensing, providing a label-free, selective, sensitive, and high-throughput platform for detecting molecular interactions. This review explores the underlying principles, instrumentation, and diverse applications of IRIS, with a focus on its efficacy for real-time monitoring of DNA-protein and protein-protein interactions, as well as virus detection. IRIS can measure DNA hybridization kinetics and identify pathogens without labeling, highlighting its versatility and reliability in biomedical research and diagnostics. IRIS achieves enhanced sensitivity and specificity by leveraging spectral reflectivity as a transduction mechanism and employing a 3D polymeric surface chemistry for bioreceptor immobilization. The review underscores IRIS's potential to revolutionize clinical diagnostics, biomolecular screening, and the study of biomolecular binding affinities, establishing it as a powerful tool for future research and medical applications.http://www.sciencedirect.com/science/article/pii/S2590137025000019Interferometric Reflectance Imaging SensorDetecting molecular interactionsBiomedical researchBiomedical diagnostics |
| spellingShingle | Monireh Bakhshpour-Yucel Nese Lortlar Unlu Elif Seymour Adil Denizli A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas Biosensors and Bioelectronics: X Interferometric Reflectance Imaging Sensor Detecting molecular interactions Biomedical research Biomedical diagnostics |
| title | A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas |
| title_full | A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas |
| title_fullStr | A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas |
| title_full_unstemmed | A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas |
| title_short | A comprehensive review of Interferometric Reflectance Imaging Sensor as a sensitive detection platform and its application areas |
| title_sort | comprehensive review of interferometric reflectance imaging sensor as a sensitive detection platform and its application areas |
| topic | Interferometric Reflectance Imaging Sensor Detecting molecular interactions Biomedical research Biomedical diagnostics |
| url | http://www.sciencedirect.com/science/article/pii/S2590137025000019 |
| work_keys_str_mv | AT monirehbakhshpouryucel acomprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT neselortlarunlu acomprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT elifseymour acomprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT adildenizli acomprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT monirehbakhshpouryucel comprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT neselortlarunlu comprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT elifseymour comprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas AT adildenizli comprehensivereviewofinterferometricreflectanceimagingsensorasasensitivedetectionplatformanditsapplicationareas |