Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer
The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of prostate cancer (PCa) patients with three classes of pathological Gleason scores (GS). Patients whose GS met these criteria (GS 3+3, GS 3+4, and GS 4+3) were included in...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/374805 |
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| author | Rajakumar Nagarajan Daniel Margolis Steven Raman Ke Sheng Christopher King Robert Reiter M. Albert Thomas |
| author_facet | Rajakumar Nagarajan Daniel Margolis Steven Raman Ke Sheng Christopher King Robert Reiter M. Albert Thomas |
| author_sort | Rajakumar Nagarajan |
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| description | The purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of prostate cancer (PCa) patients with three classes of pathological Gleason scores (GS). Patients whose GS met these criteria (GS 3+3, GS 3+4, and GS 4+3) were included in this study. The DWI was performed using 𝑏 values of 0, 50, and 400 s/mm2 in 44 patients using an endorectal coil on a 1.5T MRI scanner. The apparent diffusion coefficient (ADC) values were calculated from the DWI data of patients with three different Gleason scores. In patients with a high-grade Gleason score (4+3), the ADC values were lower in the peripheral gland tissue, pathologically determined as tumor compared to low grade (3+3 and 3+4). The mean and standard deviation of the ADC values for patients with GS 3+3, GS 3+4, and GS 4+3 were 1.135±0.119, 0.976±0.103 and 0.831±0.087 mm2/sec. The ADC values were statistically significant (𝑃<0.05) between the three different scores with a trend of decreasing ADC values with increasing Gleason scores by one-way ANOVA method. This study shows that the DWI-derived ADC values may help differentiate aggressive from low-grade PCa. |
| format | Article |
| id | doaj-art-48a2d8f549de4a9c82e9ad3344236150 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Advances in Urology |
| spelling | doaj-art-48a2d8f549de4a9c82e9ad33442361502025-02-03T01:21:47ZengWileyAdvances in Urology1687-63691687-63772012-01-01201210.1155/2012/374805374805Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate CancerRajakumar Nagarajan0Daniel Margolis1Steven Raman2Ke Sheng3Christopher King4Robert Reiter5M. Albert Thomas6Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USADepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1721, USAThe purpose of our study was to compare the apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) of prostate cancer (PCa) patients with three classes of pathological Gleason scores (GS). Patients whose GS met these criteria (GS 3+3, GS 3+4, and GS 4+3) were included in this study. The DWI was performed using 𝑏 values of 0, 50, and 400 s/mm2 in 44 patients using an endorectal coil on a 1.5T MRI scanner. The apparent diffusion coefficient (ADC) values were calculated from the DWI data of patients with three different Gleason scores. In patients with a high-grade Gleason score (4+3), the ADC values were lower in the peripheral gland tissue, pathologically determined as tumor compared to low grade (3+3 and 3+4). The mean and standard deviation of the ADC values for patients with GS 3+3, GS 3+4, and GS 4+3 were 1.135±0.119, 0.976±0.103 and 0.831±0.087 mm2/sec. The ADC values were statistically significant (𝑃<0.05) between the three different scores with a trend of decreasing ADC values with increasing Gleason scores by one-way ANOVA method. This study shows that the DWI-derived ADC values may help differentiate aggressive from low-grade PCa.http://dx.doi.org/10.1155/2012/374805 |
| spellingShingle | Rajakumar Nagarajan Daniel Margolis Steven Raman Ke Sheng Christopher King Robert Reiter M. Albert Thomas Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer Advances in Urology |
| title | Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer |
| title_full | Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer |
| title_fullStr | Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer |
| title_full_unstemmed | Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer |
| title_short | Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer |
| title_sort | correlation of gleason scores with diffusion weighted imaging findings of prostate cancer |
| url | http://dx.doi.org/10.1155/2012/374805 |
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