Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori
The prevalence of Helicobacter pylori infection is variable in different countries. There are two distinct patterns of H pylori prevalence with respect to age depending on the geographical region studied. The first pattern is widespread infection early in childhood with elevated prevalence rates of...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/132197 |
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| _version_ | 1832563076431347712 |
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| author | Carlo A Fallone |
| author_facet | Carlo A Fallone |
| author_sort | Carlo A Fallone |
| collection | DOAJ |
| description | The prevalence of Helicobacter pylori infection is variable in different countries. There are two distinct patterns of H pylori prevalence with respect to age depending on the geographical region studied. The first pattern is widespread infection early in childhood with elevated prevalence rates of close to 80% throughout adulthood, and the second is increasing prevalence with age. This variability in pattern suggests a difference in infectivity or transmissibility of H pylori infection. Potential determinants of these differences are reviewed including environmental, bacterial and host factors. The most important determinant is likely socioeconomic class, which affects living conditions and sanitation, thus altering exposure to the bacterium. Host factors also play a role, perhaps via host receptors for H pylori. Bacterial factors may also contribute, although compelling evidence is lacking. |
| format | Article |
| id | doaj-art-489176fb05c543abb71e5101f3ad541a |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-489176fb05c543abb71e5101f3ad541a2025-02-03T01:21:01ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-0113325125510.1155/1999/132197Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pyloriCarlo A Fallone0McGill University Health Centre, McGill University, Montreal, Quebec, CanadaThe prevalence of Helicobacter pylori infection is variable in different countries. There are two distinct patterns of H pylori prevalence with respect to age depending on the geographical region studied. The first pattern is widespread infection early in childhood with elevated prevalence rates of close to 80% throughout adulthood, and the second is increasing prevalence with age. This variability in pattern suggests a difference in infectivity or transmissibility of H pylori infection. Potential determinants of these differences are reviewed including environmental, bacterial and host factors. The most important determinant is likely socioeconomic class, which affects living conditions and sanitation, thus altering exposure to the bacterium. Host factors also play a role, perhaps via host receptors for H pylori. Bacterial factors may also contribute, although compelling evidence is lacking.http://dx.doi.org/10.1155/1999/132197 |
| spellingShingle | Carlo A Fallone Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori Canadian Journal of Gastroenterology |
| title | Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori |
| title_full | Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori |
| title_fullStr | Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori |
| title_full_unstemmed | Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori |
| title_short | Determinants of Ethnic or Geographical Differences in Infectivity and Transmissibility of Helicobacter pylori |
| title_sort | determinants of ethnic or geographical differences in infectivity and transmissibility of helicobacter pylori |
| url | http://dx.doi.org/10.1155/1999/132197 |
| work_keys_str_mv | AT carloafallone determinantsofethnicorgeographicaldifferencesininfectivityandtransmissibilityofhelicobacterpylori |