Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiol...
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IMR Press
2025-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26265 |
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| author | Junjie Jian Jun Wei |
| author_facet | Junjie Jian Jun Wei |
| author_sort | Junjie Jian |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tightly linked to iron metabolism, is a pivotal contributor to the oxidative stress observed in MS. Concurrently, the gut microbiota, known to affect systemic immunity and neurological health, emerges as an important regulator of iron homeostasis and inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how gut microbiota dysbiosis and ferroptosis impact MS, emphasizing their potential as therapeutic targets. Through an integrated examination of mechanistic pathways and clinical evidence, we discuss how targeting these interactions could lead to novel interventions that not only modulate disease progression but also offer personalized treatment strategies based on gut microbiota profiling. This synthesis aims at deepening insights into the microbial contributions to ferroptosis and their implications in MS, setting the stage for future research and therapeutic exploration. |
| format | Article |
| id | doaj-art-48899a1c3c8946109d1ad0260cc309d4 |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-48899a1c3c8946109d1ad0260cc309d42025-01-25T08:55:52ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-01-013012626510.31083/FBL26265S2768-6701(24)01549-1Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple SclerosisJunjie Jian0Jun Wei1The First College of Clinical Medical Science, China Three Gorges University, 443000 Yichang, Hubei, ChinaThe First College of Clinical Medical Science, China Three Gorges University, 443000 Yichang, Hubei, ChinaMultiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven by lipid peroxidation and tightly linked to iron metabolism, is a pivotal contributor to the oxidative stress observed in MS. Concurrently, the gut microbiota, known to affect systemic immunity and neurological health, emerges as an important regulator of iron homeostasis and inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how gut microbiota dysbiosis and ferroptosis impact MS, emphasizing their potential as therapeutic targets. Through an integrated examination of mechanistic pathways and clinical evidence, we discuss how targeting these interactions could lead to novel interventions that not only modulate disease progression but also offer personalized treatment strategies based on gut microbiota profiling. This synthesis aims at deepening insights into the microbial contributions to ferroptosis and their implications in MS, setting the stage for future research and therapeutic exploration.https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26265ferroptosisgut microbiotamultiple sclerosisneuroinflammationtherapeutic targets |
| spellingShingle | Junjie Jian Jun Wei Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis Frontiers in Bioscience-Landmark ferroptosis gut microbiota multiple sclerosis neuroinflammation therapeutic targets |
| title | Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis |
| title_full | Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis |
| title_fullStr | Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis |
| title_full_unstemmed | Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis |
| title_short | Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis |
| title_sort | ferroptosis a new pathway in the interaction between gut microbiota and multiple sclerosis |
| topic | ferroptosis gut microbiota multiple sclerosis neuroinflammation therapeutic targets |
| url | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL26265 |
| work_keys_str_mv | AT junjiejian ferroptosisanewpathwayintheinteractionbetweengutmicrobiotaandmultiplesclerosis AT junwei ferroptosisanewpathwayintheinteractionbetweengutmicrobiotaandmultiplesclerosis |