Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma
The aim of this study was to determine whether there are differences in complete blood count parameters (CBC) and inflammation-related biomarkers, MPV/PC, PLR, NLR, LWR, LMR, NMR, and LCR, among patients with colorectal carcinoma (CRC) and patients with colorectal adenomas. The study included 155 pa...
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| Format: | Article |
| Language: | English |
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2024-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0036 |
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| author | Koržinek Martha Ćelap Ivana Fabijanec Marija Žanić Tena Ljubičić Neven Baršić Neven Verbanac Donatella Barišić Karmela Rajković Marija Grdić |
| author_facet | Koržinek Martha Ćelap Ivana Fabijanec Marija Žanić Tena Ljubičić Neven Baršić Neven Verbanac Donatella Barišić Karmela Rajković Marija Grdić |
| author_sort | Koržinek Martha |
| collection | DOAJ |
| description | The aim of this study was to determine whether there are differences in complete blood count parameters (CBC) and inflammation-related biomarkers, MPV/PC, PLR, NLR, LWR, LMR, NMR, and LCR, among patients with colorectal carcinoma (CRC) and patients with colorectal adenomas. The study included 155 patients who were divided into two groups according to histopathological analysis – 74 adenomas patients and 81 CRC patients. A routine examination of CBC was conducted on Sysmex XN1000 whereas CRP was measured on Alinity ci-series. Statistical analysis was performed by ROC curve analysis using MedCalc Statistical Software. In CRC patients, hemoglobin concentration, hematocrit, MCV, MCH, and MCHC were lower, while RDW was higher (p < 0.001), compared to patients with adenomas. Total leukocyte count (p = 0 .006), absolute neutrophils (p = 0.005), and absolute monocytes (p = 0.007) were lower while relative eosinophils (p = 0.001) and relative basophils (p = 0.001) were higher in CRC patients. Platelet count (p < 0.001) was significantly higher and MPV (p = 0.003) was significantly lower in CRC patients. Furthermore, MPV/PC (p < 0.001) was significantly lower and PLR (p < 0.001) was significantly higher in CRC. Moreover, Receiver Operating Characteristic (ROC) analysis revealed poor diagnostic accuracy, for all tested parameters (AUC was 0.7 or less). PC, MPV, MPV/PC, and PLR were significantly different between study groups, but ROC analysis revealed poor diagnostic accuracy. Lower hemo globin levels in CRC patients are possibly due to more frequent and excessive bleeding. Higher levels of basophils and eosinophils in CRC patients are indicators of inflammatory reaction, which is linked to CRC. |
| format | Article |
| id | doaj-art-4880dcddaf064d44ae6b97ec80183c91 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-4880dcddaf064d44ae6b97ec80183c912025-02-02T15:47:25ZengSciendoActa Pharmaceutica1846-95582024-12-0174473974910.2478/acph-2024-0036Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinomaKoržinek Martha0Ćelap Ivana1Fabijanec Marija2Žanić Tena3Ljubičić Neven4Baršić Neven5Verbanac Donatella6Barišić Karmela7Rajković Marija Grdić8University of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaClinical Hospital Centre Sestre milosrdnice, Department of Gastroenterology and Hepatology10000Zagreb, CroatiaClinical Hospital Centre Sestre milosrdnice, Department of Gastroenterology and Hepatology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaUniversity of Zagreb Faculty of Pharmacy and BiochemistryDepartment of Medical Biochemistry and Hematology10000Zagreb, CroatiaThe aim of this study was to determine whether there are differences in complete blood count parameters (CBC) and inflammation-related biomarkers, MPV/PC, PLR, NLR, LWR, LMR, NMR, and LCR, among patients with colorectal carcinoma (CRC) and patients with colorectal adenomas. The study included 155 patients who were divided into two groups according to histopathological analysis – 74 adenomas patients and 81 CRC patients. A routine examination of CBC was conducted on Sysmex XN1000 whereas CRP was measured on Alinity ci-series. Statistical analysis was performed by ROC curve analysis using MedCalc Statistical Software. In CRC patients, hemoglobin concentration, hematocrit, MCV, MCH, and MCHC were lower, while RDW was higher (p < 0.001), compared to patients with adenomas. Total leukocyte count (p = 0 .006), absolute neutrophils (p = 0.005), and absolute monocytes (p = 0.007) were lower while relative eosinophils (p = 0.001) and relative basophils (p = 0.001) were higher in CRC patients. Platelet count (p < 0.001) was significantly higher and MPV (p = 0.003) was significantly lower in CRC patients. Furthermore, MPV/PC (p < 0.001) was significantly lower and PLR (p < 0.001) was significantly higher in CRC. Moreover, Receiver Operating Characteristic (ROC) analysis revealed poor diagnostic accuracy, for all tested parameters (AUC was 0.7 or less). PC, MPV, MPV/PC, and PLR were significantly different between study groups, but ROC analysis revealed poor diagnostic accuracy. Lower hemo globin levels in CRC patients are possibly due to more frequent and excessive bleeding. Higher levels of basophils and eosinophils in CRC patients are indicators of inflammatory reaction, which is linked to CRC.https://doi.org/10.2478/acph-2024-0036colorectal cancercomplete blood countinflammation-related biomarkers |
| spellingShingle | Koržinek Martha Ćelap Ivana Fabijanec Marija Žanić Tena Ljubičić Neven Baršić Neven Verbanac Donatella Barišić Karmela Rajković Marija Grdić Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma Acta Pharmaceutica colorectal cancer complete blood count inflammation-related biomarkers |
| title | Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma |
| title_full | Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma |
| title_fullStr | Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma |
| title_full_unstemmed | Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma |
| title_short | Complete blood count parameters and inflammation-related biomarkers in patients with colorectal carcinoma |
| title_sort | complete blood count parameters and inflammation related biomarkers in patients with colorectal carcinoma |
| topic | colorectal cancer complete blood count inflammation-related biomarkers |
| url | https://doi.org/10.2478/acph-2024-0036 |
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