Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India
Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population’s vulnerability, we conducted the hospital-based surveillance of respirat...
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2024-12-01
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| author | Hirawati Deval Mitali Srivastava Neha Srivastava Niraj Kumar Aman Agarwal Varsha Potdar Anita Mehta Bhoopendra Sharma Rohit Beniwal Rajeev Singh Amresh Kumar Singh Vivek Gaur Mahima Mittal Gaurav Raj Dwivedi Sthita Pragnya Behera Asif Kavathekar Sanjay Prajapati Sachin Yadav Dipti Gautam Nalin Kumar Asif Iqbal Rajni Kant Manoj Murhekar |
| author_facet | Hirawati Deval Mitali Srivastava Neha Srivastava Niraj Kumar Aman Agarwal Varsha Potdar Anita Mehta Bhoopendra Sharma Rohit Beniwal Rajeev Singh Amresh Kumar Singh Vivek Gaur Mahima Mittal Gaurav Raj Dwivedi Sthita Pragnya Behera Asif Kavathekar Sanjay Prajapati Sachin Yadav Dipti Gautam Nalin Kumar Asif Iqbal Rajni Kant Manoj Murhekar |
| author_sort | Hirawati Deval |
| collection | DOAJ |
| description | Acute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population’s vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh. Throat and nasal swabs were collected from outpatients and inpatients in the Department of Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 and April 2023. A total of 943 samples from children aged 1 to 60 months were tested using multiplex real-time PCR for respiratory viruses in cases of ARI and SARI. Out of 943 samples tested, the highest positivity was found for parainfluenza virus [105 (11.13%) PIV-1 (79), PIV-2 (18), PIV-4 (18)], followed by adenovirus [82 (8.7%), RSV-B, [68 (7.21%)], influenza-A [46(4.9%): H1N1 = 29, H3N2 = 14), SARS CoV-2 [28 (3%)], hMPV [13(1.4%), RSV-A [4 (0.42%), and influenza-B (Victoria lineage) 1 (0.10%). The maximum positivity of respiratory viruses was seen in children between 1 to 12 months. The wide variation in prevalence of these respiratory viruses was seen in different seasons. This study enhances understanding of the seasonal and clinical trends of respiratory virus circulation and co-infections in Eastern Uttar Pradesh. The findings highlight the importance of targeted interventions to reduce the burden of respiratory infections in this region. |
| format | Article |
| id | doaj-art-487bafa42017458a833d23ac3f72900a |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-487bafa42017458a833d23ac3f72900a2025-01-24T13:52:18ZengMDPI AGViruses1999-49152024-12-011712710.3390/v17010027Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, IndiaHirawati Deval0Mitali Srivastava1Neha Srivastava2Niraj Kumar3Aman Agarwal4Varsha Potdar5Anita Mehta6Bhoopendra Sharma7Rohit Beniwal8Rajeev Singh9Amresh Kumar Singh10Vivek Gaur11Mahima Mittal12Gaurav Raj Dwivedi13Sthita Pragnya Behera14Asif Kavathekar15Sanjay Prajapati16Sachin Yadav17Dipti Gautam18Nalin Kumar19Asif Iqbal20Rajni Kant21Manoj Murhekar22Molecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaNational Influenza Centre, ICMR-National Institute of Virology, Pune 411001, IndiaDepartment of Paediatrics, BRD Medical College, Gorakhpur 273013, IndiaDepartment of Paediatrics, BRD Medical College, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaDepartment of Microbiology, BRD Medical College, Gorakhpur 273013, IndiaDepartment of Microbiology, BRD Medical College, Gorakhpur 273013, IndiaDepartment of Paediatrics, AIIMS, Gorakhpur 273008, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaMolecular Biology Division, ICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-Regional Medical Research Centre, Gorakhpur 273013, IndiaICMR-National Institute of Epidemiology, Chennai 600077, IndiaAcute respiratory infections (ARIs) are a leading cause of death in children under five globally. The seasonal trends and profiles of respiratory viruses vary by region and season. Due to limited information and the population’s vulnerability, we conducted the hospital-based surveillance of respiratory viruses in Eastern Uttar Pradesh. Throat and nasal swabs were collected from outpatients and inpatients in the Department of Paediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, between May 2022 and April 2023. A total of 943 samples from children aged 1 to 60 months were tested using multiplex real-time PCR for respiratory viruses in cases of ARI and SARI. Out of 943 samples tested, the highest positivity was found for parainfluenza virus [105 (11.13%) PIV-1 (79), PIV-2 (18), PIV-4 (18)], followed by adenovirus [82 (8.7%), RSV-B, [68 (7.21%)], influenza-A [46(4.9%): H1N1 = 29, H3N2 = 14), SARS CoV-2 [28 (3%)], hMPV [13(1.4%), RSV-A [4 (0.42%), and influenza-B (Victoria lineage) 1 (0.10%). The maximum positivity of respiratory viruses was seen in children between 1 to 12 months. The wide variation in prevalence of these respiratory viruses was seen in different seasons. This study enhances understanding of the seasonal and clinical trends of respiratory virus circulation and co-infections in Eastern Uttar Pradesh. The findings highlight the importance of targeted interventions to reduce the burden of respiratory infections in this region.https://www.mdpi.com/1999-4915/17/1/27ARIhuman metapneumovirus (hMPV)parainfluenza virus (PIV)respiratory syncytial virus (RSV)severe acute respiratory infectionunder 5 children |
| spellingShingle | Hirawati Deval Mitali Srivastava Neha Srivastava Niraj Kumar Aman Agarwal Varsha Potdar Anita Mehta Bhoopendra Sharma Rohit Beniwal Rajeev Singh Amresh Kumar Singh Vivek Gaur Mahima Mittal Gaurav Raj Dwivedi Sthita Pragnya Behera Asif Kavathekar Sanjay Prajapati Sachin Yadav Dipti Gautam Nalin Kumar Asif Iqbal Rajni Kant Manoj Murhekar Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India Viruses ARI human metapneumovirus (hMPV) parainfluenza virus (PIV) respiratory syncytial virus (RSV) severe acute respiratory infection under 5 children |
| title | Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India |
| title_full | Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India |
| title_fullStr | Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India |
| title_full_unstemmed | Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India |
| title_short | Hospital-Based Surveillance of Respiratory Viruses Among Children Under Five Years of Age with ARI and SARI in Eastern UP, India |
| title_sort | hospital based surveillance of respiratory viruses among children under five years of age with ari and sari in eastern up india |
| topic | ARI human metapneumovirus (hMPV) parainfluenza virus (PIV) respiratory syncytial virus (RSV) severe acute respiratory infection under 5 children |
| url | https://www.mdpi.com/1999-4915/17/1/27 |
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