Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens
The growing frequency of antibiotic-resistant microorganisms requires novel antimicrobial methods. Quorum Sensing (QS), a bacterial communication system, is critical for controlling virulence factors and biofilm development, contributing to many foodborne bacteria' pathogenicity. Garlic, a n...
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| Language: | English |
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PAGEPress Publications
2025-01-01
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| Series: | Journal of Biological Research |
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| Online Access: | https://www.pagepressjournals.org/jbr/article/view/13130 |
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| _version_ | 1832590600834121728 |
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| author | Mahmoud Dahab Mohammed Aladhadh |
| author_facet | Mahmoud Dahab Mohammed Aladhadh |
| author_sort | Mahmoud Dahab |
| collection | DOAJ |
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The growing frequency of antibiotic-resistant microorganisms requires novel antimicrobial methods. Quorum Sensing (QS), a bacterial communication system, is critical for controlling virulence factors and biofilm development, contributing to many foodborne bacteria' pathogenicity. Garlic, a natural substance, is a widely consumed plant with antimicrobial properties and antibacterial capabilities, although its peptide components are poorly unknown. This study evaluated garlic-derived peptides' ability to inhibit QS in foodborne bacteria. Two garlic-derived peptides, including VS-9 and F3-3-c, undergo bioinformatics research to determine their structural features, bioactivity, physicochemical parameters, and potential interactions with target modeled proteins of LasR QS from Pseudomonas aeruginosa, Biofilm-associated surface protein (Baps) from Staphylococcus aureus, and sortase A (SrtA) from Staphylococcus aureus. VS-9 has the most favorable structure properties, which could be essential for its inhibitory activity against LasR, Baps, and SrtA proteins. We have modeled, characterized, and docked garlic-derived peptides to assess their antimicrobial properties. Even though VS-9 showed more anti QS activity than F3-3-c, more research is needed to fully understand their mechanisms of action and maximize their therapeutic potential.
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| format | Article |
| id | doaj-art-485c21e40bf64b9c89456566ba39c2e7 |
| institution | Kabale University |
| issn | 1826-8838 2284-0230 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj-art-485c21e40bf64b9c89456566ba39c2e72025-01-23T10:55:56ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302025-01-0110.4081/jbr.2025.13130Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogensMahmoud Dahab0Mohammed Aladhadh1Faculty of Pharmacy, University of Malaya, Wilayah Persekutuan Kuala LumpurDepartment of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, Buraydah The growing frequency of antibiotic-resistant microorganisms requires novel antimicrobial methods. Quorum Sensing (QS), a bacterial communication system, is critical for controlling virulence factors and biofilm development, contributing to many foodborne bacteria' pathogenicity. Garlic, a natural substance, is a widely consumed plant with antimicrobial properties and antibacterial capabilities, although its peptide components are poorly unknown. This study evaluated garlic-derived peptides' ability to inhibit QS in foodborne bacteria. Two garlic-derived peptides, including VS-9 and F3-3-c, undergo bioinformatics research to determine their structural features, bioactivity, physicochemical parameters, and potential interactions with target modeled proteins of LasR QS from Pseudomonas aeruginosa, Biofilm-associated surface protein (Baps) from Staphylococcus aureus, and sortase A (SrtA) from Staphylococcus aureus. VS-9 has the most favorable structure properties, which could be essential for its inhibitory activity against LasR, Baps, and SrtA proteins. We have modeled, characterized, and docked garlic-derived peptides to assess their antimicrobial properties. Even though VS-9 showed more anti QS activity than F3-3-c, more research is needed to fully understand their mechanisms of action and maximize their therapeutic potential. https://www.pagepressjournals.org/jbr/article/view/13130Quorum sensingantimicrobial peptidesgarlicfoodborne pathogensbioinformaticsdrug design |
| spellingShingle | Mahmoud Dahab Mohammed Aladhadh Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens Journal of Biological Research Quorum sensing antimicrobial peptides garlic foodborne pathogens bioinformatics drug design |
| title | Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens |
| title_full | Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens |
| title_fullStr | Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens |
| title_full_unstemmed | Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens |
| title_short | Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens |
| title_sort | bioinformatics exploration of identified garlic derived antimicrobial peptides a food based approach to quorum sensing inhibition in foodborne pathogens |
| topic | Quorum sensing antimicrobial peptides garlic foodborne pathogens bioinformatics drug design |
| url | https://www.pagepressjournals.org/jbr/article/view/13130 |
| work_keys_str_mv | AT mahmouddahab bioinformaticsexplorationofidentifiedgarlicderivedantimicrobialpeptidesafoodbasedapproachtoquorumsensinginhibitioninfoodbornepathogens AT mohammedaladhadh bioinformaticsexplorationofidentifiedgarlicderivedantimicrobialpeptidesafoodbasedapproachtoquorumsensinginhibitioninfoodbornepathogens |