IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging
The tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca2+ signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy. Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/920178 |
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| _version_ | 1832563425171996672 |
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| author | Jean-Paul Decuypere Giovanni Monaco Ludwig Missiaen Humbert De Smedt Jan B. Parys Geert Bultynck |
| author_facet | Jean-Paul Decuypere Giovanni Monaco Ludwig Missiaen Humbert De Smedt Jan B. Parys Geert Bultynck |
| author_sort | Jean-Paul Decuypere |
| collection | DOAJ |
| description | The tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca2+ signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy. Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics and homeostasis through binding and modulation of the intracellular Ca2+-release and Ca2+-uptake mechanisms. During aging, oxidative stress becomes an additional factor that affects ER and mitochondrial function and thus their role in Ca2+ signaling. Importantly, mitochondrial dysfunction and sustained mitochondrial damage are likely to underlie part of the aging process. In this paper, we will discuss the different mechanisms that control intracellular Ca2+ signaling with respect to apoptosis and autophagy and review how these processes are affected during aging through accumulation of reactive oxygen species. |
| format | Article |
| id | doaj-art-485b0c037a95447b8fedd8a7f3567bb7 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-485b0c037a95447b8fedd8a7f3567bb72025-02-03T01:20:10ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/920178920178IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for AgingJean-Paul Decuypere0Giovanni Monaco1Ludwig Missiaen2Humbert De Smedt3Jan B. Parys4Geert Bultynck5Laboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumLaboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumLaboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumLaboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumLaboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumLaboratory of Molecular and Cellular Signaling, Department of Molecular and Cellular Biology, K.U.Leuven, Campus Gasthuisberg O/N-1, Herestraat 49, Bus 802, 3000 Leuven, BelgiumThe tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca2+ signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy. Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics and homeostasis through binding and modulation of the intracellular Ca2+-release and Ca2+-uptake mechanisms. During aging, oxidative stress becomes an additional factor that affects ER and mitochondrial function and thus their role in Ca2+ signaling. Importantly, mitochondrial dysfunction and sustained mitochondrial damage are likely to underlie part of the aging process. In this paper, we will discuss the different mechanisms that control intracellular Ca2+ signaling with respect to apoptosis and autophagy and review how these processes are affected during aging through accumulation of reactive oxygen species.http://dx.doi.org/10.4061/2011/920178 |
| spellingShingle | Jean-Paul Decuypere Giovanni Monaco Ludwig Missiaen Humbert De Smedt Jan B. Parys Geert Bultynck IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging Journal of Aging Research |
| title | IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging |
| title_full | IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging |
| title_fullStr | IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging |
| title_full_unstemmed | IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging |
| title_short | IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging |
| title_sort | ip3 receptors mitochondria and ca2 signaling implications for aging |
| url | http://dx.doi.org/10.4061/2011/920178 |
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