Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems
The aim of this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-FU) controlled release. Chitosan microspheres were prepared by precipitation method and the effects of manufacturing parameters (injection and airflow rates) on size d...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Chemical Engineering |
| Online Access: | http://dx.doi.org/10.1155/2018/2340249 |
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| author | Hanniman Denizard Cosme Barbosa Bárbara Fernanda Figueiredo dos Santos Albaniza Alves Tavares Rossemberg Cardoso Barbosa Marcus Vinícius Lia Fook Eduardo Luis Canedo Suédina Maria de Lima Silva |
| author_facet | Hanniman Denizard Cosme Barbosa Bárbara Fernanda Figueiredo dos Santos Albaniza Alves Tavares Rossemberg Cardoso Barbosa Marcus Vinícius Lia Fook Eduardo Luis Canedo Suédina Maria de Lima Silva |
| author_sort | Hanniman Denizard Cosme Barbosa |
| collection | DOAJ |
| description | The aim of this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-FU) controlled release. Chitosan microspheres were prepared by precipitation method and the effects of manufacturing parameters (injection and airflow rates) on size distribution microspheres were analyzed by optical and scanning electron microscopy. The results show that the manufacturing parameters, injection and airflow rates, determine the microsphere size distribution. By modulating these parameters, it was possible to produce chitosan microspheres as small as 437 ± 44 μm and as large as 993 ± 18 μm. Chitosan microspheres loaded with 5-FU were also produced using the experimental equipment. The obtained microspheres presented 5-FU controlled release, indicating that the microspheres can be used orally, since they are capable of crossing the stomach barrier and of continuing with the process of 5-FU release. |
| format | Article |
| id | doaj-art-4859c349565446279a7c5dba3bca29e3 |
| institution | Kabale University |
| issn | 1687-806X 1687-8078 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Chemical Engineering |
| spelling | doaj-art-4859c349565446279a7c5dba3bca29e32025-02-03T06:46:03ZengWileyInternational Journal of Chemical Engineering1687-806X1687-80782018-01-01201810.1155/2018/23402492340249Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release SystemsHanniman Denizard Cosme Barbosa0Bárbara Fernanda Figueiredo dos Santos1Albaniza Alves Tavares2Rossemberg Cardoso Barbosa3Marcus Vinícius Lia Fook4Eduardo Luis Canedo5Suédina Maria de Lima Silva6Department of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilThe aim of this study was to develop an inexpensive apparatus for fabricating microspheres, based on chitosan, for 5-fluorouracil (5-FU) controlled release. Chitosan microspheres were prepared by precipitation method and the effects of manufacturing parameters (injection and airflow rates) on size distribution microspheres were analyzed by optical and scanning electron microscopy. The results show that the manufacturing parameters, injection and airflow rates, determine the microsphere size distribution. By modulating these parameters, it was possible to produce chitosan microspheres as small as 437 ± 44 μm and as large as 993 ± 18 μm. Chitosan microspheres loaded with 5-FU were also produced using the experimental equipment. The obtained microspheres presented 5-FU controlled release, indicating that the microspheres can be used orally, since they are capable of crossing the stomach barrier and of continuing with the process of 5-FU release.http://dx.doi.org/10.1155/2018/2340249 |
| spellingShingle | Hanniman Denizard Cosme Barbosa Bárbara Fernanda Figueiredo dos Santos Albaniza Alves Tavares Rossemberg Cardoso Barbosa Marcus Vinícius Lia Fook Eduardo Luis Canedo Suédina Maria de Lima Silva Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems International Journal of Chemical Engineering |
| title | Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems |
| title_full | Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems |
| title_fullStr | Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems |
| title_full_unstemmed | Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems |
| title_short | Inexpensive Apparatus for Fabricating Microspheres for 5-Fluorouracil Controlled Release Systems |
| title_sort | inexpensive apparatus for fabricating microspheres for 5 fluorouracil controlled release systems |
| url | http://dx.doi.org/10.1155/2018/2340249 |
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