Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases

Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases

CRISPR-associated endoribonucleases (Cas RNases) cleave single-stranded RNA in a highly sequence-specific manner by recognizing and binding to short RNA sequences known as direct repeats (DRs). Here, we investigate the potential of exploiting Cas RNases for the regulation of target genes with one or...

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Bibliographic Details
Main Authors: Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Derek S. Maranan, Dylan D. Butler, Abigail Wiseman, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Cells
Subjects:
CRISPR
direct repeat
endoribonuclease
gene regulation
RNA interference
Online Access:https://www.mdpi.com/2073-4409/14/7/543
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