Emerging Stem Cell Therapies: Treatment, Safety, and Biology
Stem cells are the fundamental building blocks of life and contribute to the genesis and development of all higher organisms. The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal condit...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/521343 |
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| _version_ | 1832564952166039552 |
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| author | Joel Sng Thomas Lufkin |
| author_facet | Joel Sng Thomas Lufkin |
| author_sort | Joel Sng |
| collection | DOAJ |
| description | Stem cells are the fundamental building blocks of life and contribute to the genesis and development of all higher organisms. The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal conditions. Hematopoietic stem cell transplantation was the first example of a successful stem cell therapy and is widely utilized for treating various diseases including adult T-cell leukemia-lymphoma and multiple myeloma. The autologous transplantation of mesenchymal stem cells is increasingly employed to catalyze the repair of mesenchymal tissue and others, including the lung and heart, and utilized in treating various conditions such as stroke, multiple sclerosis, and diabetes. There is also increasing interest in the therapeutic potential of other adult stem cells such as neural, mammary, intestinal, inner ear, and testicular stem cells. The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies. |
| format | Article |
| id | doaj-art-4827779fde6c410da51e43c3eba5ba66 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4827779fde6c410da51e43c3eba5ba662025-02-03T01:09:45ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/521343521343Emerging Stem Cell Therapies: Treatment, Safety, and BiologyJoel Sng0Thomas Lufkin1Stem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, SingaporeStem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, 138672, SingaporeStem cells are the fundamental building blocks of life and contribute to the genesis and development of all higher organisms. The discovery of adult stem cells has led to an ongoing revolution of therapeutic and regenerative medicine and the proposal of novel therapies for previously terminal conditions. Hematopoietic stem cell transplantation was the first example of a successful stem cell therapy and is widely utilized for treating various diseases including adult T-cell leukemia-lymphoma and multiple myeloma. The autologous transplantation of mesenchymal stem cells is increasingly employed to catalyze the repair of mesenchymal tissue and others, including the lung and heart, and utilized in treating various conditions such as stroke, multiple sclerosis, and diabetes. There is also increasing interest in the therapeutic potential of other adult stem cells such as neural, mammary, intestinal, inner ear, and testicular stem cells. The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies.http://dx.doi.org/10.1155/2012/521343 |
| spellingShingle | Joel Sng Thomas Lufkin Emerging Stem Cell Therapies: Treatment, Safety, and Biology Stem Cells International |
| title | Emerging Stem Cell Therapies: Treatment, Safety, and Biology |
| title_full | Emerging Stem Cell Therapies: Treatment, Safety, and Biology |
| title_fullStr | Emerging Stem Cell Therapies: Treatment, Safety, and Biology |
| title_full_unstemmed | Emerging Stem Cell Therapies: Treatment, Safety, and Biology |
| title_short | Emerging Stem Cell Therapies: Treatment, Safety, and Biology |
| title_sort | emerging stem cell therapies treatment safety and biology |
| url | http://dx.doi.org/10.1155/2012/521343 |
| work_keys_str_mv | AT joelsng emergingstemcelltherapiestreatmentsafetyandbiology AT thomaslufkin emergingstemcelltherapiestreatmentsafetyandbiology |