Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents
Introduction. Recurrent extreme hyperferritinemia (ferritin >10,000 ng/mL) was noted in 4 critically ill adolescents prior to death, though this association has not previously been described. Methods. A retrospective review of the medical records of 4 critically ill adolescents with recurrent ext...
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Wiley
2022-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/6207417 |
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| author | John Scott Baird |
| author_facet | John Scott Baird |
| author_sort | John Scott Baird |
| collection | DOAJ |
| description | Introduction. Recurrent extreme hyperferritinemia (ferritin >10,000 ng/mL) was noted in 4 critically ill adolescents prior to death, though this association has not previously been described. Methods. A retrospective review of the medical records of 4 critically ill adolescents with recurrent extreme hyperferritinemia and systemic inflammation was performed to identify additional common epidemiologic factors. Results. Systemic inflammation was characterized as cytokine storm syndrome in 2 patients and hemophagocytic lymphohistiocytosis in 2 patients. Episodes of extreme hyperferritinemia were noted on at least 2 different dates in all patients; these episodes (n = 10) were separated by an interval of 2 weeks to several months and were usually (in 8 of 10 episodes) associated with the onset or worsening of multiple organ dysfunction syndrome. Death occurred within 2 weeks of the onset of an episode of recurrent extreme hyperferritinemia. Lymphocytopenia and cachexia were noted in all patients. Conclusions. Recurrent extreme hyperferritinemia—often with multiple organ dysfunction syndrome—was noted in 4 adolescents with systemic inflammation who did not survive their critical illness. Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism. |
| format | Article |
| id | doaj-art-48276d273d4d4a96b25a2d5ea6063929 |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-48276d273d4d4a96b25a2d5ea60639292025-02-03T06:01:52ZengWileyInternational Journal of Inflammation2042-00992022-01-01202210.1155/2022/6207417Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill AdolescentsJohn Scott Baird0Department of PediatricsIntroduction. Recurrent extreme hyperferritinemia (ferritin >10,000 ng/mL) was noted in 4 critically ill adolescents prior to death, though this association has not previously been described. Methods. A retrospective review of the medical records of 4 critically ill adolescents with recurrent extreme hyperferritinemia and systemic inflammation was performed to identify additional common epidemiologic factors. Results. Systemic inflammation was characterized as cytokine storm syndrome in 2 patients and hemophagocytic lymphohistiocytosis in 2 patients. Episodes of extreme hyperferritinemia were noted on at least 2 different dates in all patients; these episodes (n = 10) were separated by an interval of 2 weeks to several months and were usually (in 8 of 10 episodes) associated with the onset or worsening of multiple organ dysfunction syndrome. Death occurred within 2 weeks of the onset of an episode of recurrent extreme hyperferritinemia. Lymphocytopenia and cachexia were noted in all patients. Conclusions. Recurrent extreme hyperferritinemia—often with multiple organ dysfunction syndrome—was noted in 4 adolescents with systemic inflammation who did not survive their critical illness. Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism.http://dx.doi.org/10.1155/2022/6207417 |
| spellingShingle | John Scott Baird Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents International Journal of Inflammation |
| title | Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents |
| title_full | Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents |
| title_fullStr | Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents |
| title_full_unstemmed | Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents |
| title_short | Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents |
| title_sort | mortality associated with recurrent extreme hyperferritinemia in critically ill adolescents |
| url | http://dx.doi.org/10.1155/2022/6207417 |
| work_keys_str_mv | AT johnscottbaird mortalityassociatedwithrecurrentextremehyperferritinemiaincriticallyilladolescents |