Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6

Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6

Abstract Background Colorectal cancer (CRC) is one of the deadliest malignancies worldwide characterized by rapid progression, high metastasis propensity. Our study aimed to identify the driving biological factors of metastatic CRC. Methods We obtained frozen tumor tissues of 8 metastatic CRC (mCRC)...

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Main Authors: Yimei Jiang, Zhe Li, Fang Zheng, Wenqing Jia, Zichao Guo, Zhuoqing Xu, Chenhao Huang, Zhiliang Li, Changgang Wang, Kun Liu, Haoran Feng, Ren Zhao, Xi Cheng
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Metastasis
Multi-omics
RPS6 phosphorylation
Online Access:https://doi.org/10.1186/s12935-025-03924-6
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https://doi.org/10.1186/s12935-025-03924-6

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