The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability
Abstract Background Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. Sickle vasculopathy caused by impaired nitric oxide bioavailability and arterial stiffness and associated with multiple complications. Results Mean age of patien...
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SpringerOpen
2025-01-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | https://doi.org/10.1186/s43055-024-01416-7 |
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| author | Marwa Mohammed Mohammed Onsy Sonia Ali El-Saiedi Douaa Mohammed Mohammed Elsheshtawy Marwa Abd-Elhady Abd-Elsamad |
| author_facet | Marwa Mohammed Mohammed Onsy Sonia Ali El-Saiedi Douaa Mohammed Mohammed Elsheshtawy Marwa Abd-Elhady Abd-Elsamad |
| author_sort | Marwa Mohammed Mohammed Onsy |
| collection | DOAJ |
| description | Abstract Background Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. Sickle vasculopathy caused by impaired nitric oxide bioavailability and arterial stiffness and associated with multiple complications. Results Mean age of patients was 13.85 ± 2.53 SD, 50% were males, 77.5% were homozygous sickle cell disease (SS). Brachial artery parameters showed that baseline diameter was significantly higher (p < 0.001) and flow mediated dilatation (FMD) was significantly lower in patients than control (p < 0.001). Carotid artery parameters showed that carotid intima-media thickness (CIMT) and cross-sectional distensability were significantly higher in sickle group than control (p 0.001, p 0.007). Diastolic shear stress and elastic modulus showed no significant difference between sickle and control group (p 0.071, p 0.083). Regarding sickle subgroups, carotid intima-media thickness was higher and cross-sectional compliance and distensability were lower in subgroup II than subgroup I (p < 0.001, p < 0.018, p < 0.035), respectively. Conclusion Doppler assessment of brachial and carotid elastic properties may be helpful for early detection of sickle cell vasculopathy and sickle-related complications. |
| format | Article |
| id | doaj-art-4820ee06040d4c8bb589661f1ae0d918 |
| institution | Kabale University |
| issn | 2090-4762 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj-art-4820ee06040d4c8bb589661f1ae0d9182025-01-26T12:21:36ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622025-01-0156111210.1186/s43055-024-01416-7The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailabilityMarwa Mohammed Mohammed Onsy0Sonia Ali El-Saiedi1Douaa Mohammed Mohammed Elsheshtawy2Marwa Abd-Elhady Abd-Elsamad3Department of Diagnostic and Interventional Radiology, Kasr Al Ainy Faculty of Medicine, Cairo UniversityDepartment of pediatrics, Kasr Al Ainy Faculty of Medicine, Cairo UniversityDepartment of pediatrics, Kasr Al Ainy Faculty of Medicine, Cairo UniversityDepartment of pediatrics, Kasr Al Ainy Faculty of Medicine, Cairo UniversityAbstract Background Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. Sickle vasculopathy caused by impaired nitric oxide bioavailability and arterial stiffness and associated with multiple complications. Results Mean age of patients was 13.85 ± 2.53 SD, 50% were males, 77.5% were homozygous sickle cell disease (SS). Brachial artery parameters showed that baseline diameter was significantly higher (p < 0.001) and flow mediated dilatation (FMD) was significantly lower in patients than control (p < 0.001). Carotid artery parameters showed that carotid intima-media thickness (CIMT) and cross-sectional distensability were significantly higher in sickle group than control (p 0.001, p 0.007). Diastolic shear stress and elastic modulus showed no significant difference between sickle and control group (p 0.071, p 0.083). Regarding sickle subgroups, carotid intima-media thickness was higher and cross-sectional compliance and distensability were lower in subgroup II than subgroup I (p < 0.001, p < 0.018, p < 0.035), respectively. Conclusion Doppler assessment of brachial and carotid elastic properties may be helpful for early detection of sickle cell vasculopathy and sickle-related complications.https://doi.org/10.1186/s43055-024-01416-7Sickle vasculopathyArterial stiffnessCIMTComplianceDistensabilityElastic modulus |
| spellingShingle | Marwa Mohammed Mohammed Onsy Sonia Ali El-Saiedi Douaa Mohammed Mohammed Elsheshtawy Marwa Abd-Elhady Abd-Elsamad The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability The Egyptian Journal of Radiology and Nuclear Medicine Sickle vasculopathy Arterial stiffness CIMT Compliance Distensability Elastic modulus |
| title | The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| title_full | The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| title_fullStr | The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| title_full_unstemmed | The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| title_short | The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| title_sort | added role of doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability |
| topic | Sickle vasculopathy Arterial stiffness CIMT Compliance Distensability Elastic modulus |
| url | https://doi.org/10.1186/s43055-024-01416-7 |
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