Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains

Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains

<b>Background/Objectives</b>: Yellow fever virus (YFV) (<i>Flaviviridae</i>, <i>Orthoflavivirus</i>) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a hi...

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Bibliographic Details
Main Authors: Ana C. B. Terzian, Sasha R. Azar, Cassia F. Estofolete, Mauricio L. Nogueira, Nikos Vasilakis
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Vaccines
Subjects:
YFV
vaccine
immune response
neutralizing antibodies
Online Access:https://www.mdpi.com/2076-393X/12/12/1311
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Summary:<b>Background/Objectives</b>: Yellow fever virus (YFV) (<i>Flaviviridae</i>, <i>Orthoflavivirus</i>) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a highly efficacious and safe vaccine (17D). Vaccination provides lifelong protection from YF disease mediated by humoral immunity. There are several versions of the original 17D vaccine: 17D-204 (marketed in the USA as YF-VAX, in France as Stamaril, and in China as Tiantan-V), 17D-213 (Russian Federation), and 17DD (by FIOCRUZ in Brazil). Vaccines produced in the US, France, Senegal, China, and Russia represent 17D-204-derived strains, whereas the Brazilian 17DD has a unique passage/attenuation history from 17D-204-derived strains. Their functional differences in the neutralization profiles are not known. <b>Methods</b>: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. <b>Results</b>: Sera exhibited significantly more efficient neutralization of 17DD (mean reciprocal PRNT<sub>50</sub> 183, PRNT<sub>80</sub> 86, median reciprocal PRNT<sub>50</sub> 80, and PRNT<sub>80</sub> 40) compared to 17D-204 (mean reciprocal PRNT<sub>50</sub> 91, PRNT<sub>80</sub> 33, median reciprocal PRNT<sub>50</sub> 40, and PRNT<sub>80</sub> 10). <b>Conclusions</b>: Our data indicate antigenic differences between 17D and 17DD vaccines.
ISSN:2076-393X

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