Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery?
Abstract Background Artcure diffusional patch (ADP) is a novel transdermal therapeutic system that started to be used in the last decade for lumbar disc herniation (LDH). Previous studies have reported early results of the therapy. In this study, we aimed to evaluate the medium- to long-term functio...
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2025-01-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08314-7 |
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| author | Zekeriya Ersin Çelen Furkan Hanege Soner Sarı Bülent Özkurt |
| author_facet | Zekeriya Ersin Çelen Furkan Hanege Soner Sarı Bülent Özkurt |
| author_sort | Zekeriya Ersin Çelen |
| collection | DOAJ |
| description | Abstract Background Artcure diffusional patch (ADP) is a novel transdermal therapeutic system that started to be used in the last decade for lumbar disc herniation (LDH). Previous studies have reported early results of the therapy. In this study, we aimed to evaluate the medium- to long-term functional outcomes of this treatment in LDH patients and examine factors predicting the need for surgery after treatment. Methods Totally, 270 patients with single-level LDH were included. ADP was applied transdermally to the lumbar regions of the patients. Outcomes measures included the Oswestry Disability Index (ODI) and leg and low back visual analog scales (VAS). Herniations were graded using the Michigan State University (MSU) classification. The predictive factors for surgery need were analyzed with logistic regression analysis. Results The average follow-up duration was 43.8 ± 4.8 months. The average VAS and ODI scores of the patients decreased significantly at the first month and final visits compared to admission values (p < 0.001). Within the follow-up period, 19 (7.0%) patients underwent surgery. The results of the multivariate analysis showed that ≥ 2 MSU grade of the herniation was a significant predictive factor for operation need (HR: 7.32 (1.87–28.57), p = 0.004). Conclusion Single-dose ADP therapy is a safe and feasible treatment option in the treatment of single-level LDH and can achieve favorable functional and pain scores at medium- to long-term. Patients with MSU grade two and three herniations should be monitored more closely, as they are more likely to experience a later surgical intervention. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-481b914837004aeda2b5043171a83fe7 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-481b914837004aeda2b5043171a83fe72025-01-19T12:04:36ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-0126111010.1186/s12891-025-08314-7Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery?Zekeriya Ersin Çelen0Furkan Hanege1Soner Sarı2Bülent Özkurt3Department of Orthopaedics and Traumatology, Yalova Training and Research HospitalDepartment of Orthopaedics and Traumatology, Ankara Bilkent City Hospital, University of Health SciencesDepartment of Orthopaedics and Traumatology, Ankara Bilkent City Hospital, University of Health SciencesDepartment of Orthopaedics and Traumatology, Ankara Bilkent City Hospital, University of Health SciencesAbstract Background Artcure diffusional patch (ADP) is a novel transdermal therapeutic system that started to be used in the last decade for lumbar disc herniation (LDH). Previous studies have reported early results of the therapy. In this study, we aimed to evaluate the medium- to long-term functional outcomes of this treatment in LDH patients and examine factors predicting the need for surgery after treatment. Methods Totally, 270 patients with single-level LDH were included. ADP was applied transdermally to the lumbar regions of the patients. Outcomes measures included the Oswestry Disability Index (ODI) and leg and low back visual analog scales (VAS). Herniations were graded using the Michigan State University (MSU) classification. The predictive factors for surgery need were analyzed with logistic regression analysis. Results The average follow-up duration was 43.8 ± 4.8 months. The average VAS and ODI scores of the patients decreased significantly at the first month and final visits compared to admission values (p < 0.001). Within the follow-up period, 19 (7.0%) patients underwent surgery. The results of the multivariate analysis showed that ≥ 2 MSU grade of the herniation was a significant predictive factor for operation need (HR: 7.32 (1.87–28.57), p = 0.004). Conclusion Single-dose ADP therapy is a safe and feasible treatment option in the treatment of single-level LDH and can achieve favorable functional and pain scores at medium- to long-term. Patients with MSU grade two and three herniations should be monitored more closely, as they are more likely to experience a later surgical intervention. Clinical trial number Not applicable.https://doi.org/10.1186/s12891-025-08314-7Transdermal patchIntervertebral disc herniationVisual analog scaleMagnetic resonance imagingArtcure diffusional patchMSU classification |
| spellingShingle | Zekeriya Ersin Çelen Furkan Hanege Soner Sarı Bülent Özkurt Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? BMC Musculoskeletal Disorders Transdermal patch Intervertebral disc herniation Visual analog scale Magnetic resonance imaging Artcure diffusional patch MSU classification |
| title | Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? |
| title_full | Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? |
| title_fullStr | Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? |
| title_full_unstemmed | Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? |
| title_short | Medium- to long-term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation: which herniation is more likely to require surgery? |
| title_sort | medium to long term functional outcomes of artcure diffusional patch therapy for lumbar disc herniation which herniation is more likely to require surgery |
| topic | Transdermal patch Intervertebral disc herniation Visual analog scale Magnetic resonance imaging Artcure diffusional patch MSU classification |
| url | https://doi.org/10.1186/s12891-025-08314-7 |
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