Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study
Abstract Objective To analyze the characteristics of pulmonary nodules (PNs) and related influencing factors in patients with type 2 diabetes mellitus (T2DM). Methods Retrospectively analyzed the clinical and biochemical characteristics of 224 patients with PNs and 488 patients with non-PNs in patie...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-01857-9 |
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| author | Jie Yang Wenna Wang Yizhen Lu Chunyao Li Shuwu Wei Weiwei Sun |
| author_facet | Jie Yang Wenna Wang Yizhen Lu Chunyao Li Shuwu Wei Weiwei Sun |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Abstract Objective To analyze the characteristics of pulmonary nodules (PNs) and related influencing factors in patients with type 2 diabetes mellitus (T2DM). Methods Retrospectively analyzed the clinical and biochemical characteristics of 224 patients with PNs and 488 patients with non-PNs in patients with T2DM, and compared the clinical data of 72 patients with large nodules (≥ 5 mm) and 152 patients with small nodules (< 5 mm) in the pulmonary nodules (PNs) group. Results Compared to the non-PNs group, the PNs Patients in the group had a longer duration of diabetes, higher age, serum creatinine (SCR), blood urea nitrogen (BUN) and the lower albumin (ALB) and body mass index (BMI); women, diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and estimated glomerular filtration rate (eGFR) < 60 ml/min1.73m2 were more represented in the PNs group; there were fewer patients with overweight in the PNs group. Age and eGFR < 60 ml/min/1.73m2 were independent risk factors for PNs in patients with T2DM, and overweight was associated with a reduced risk of PNs. Compared with the small nodule group, patients in the large nodule group had higher fasting blood glucose (FBG) and lower fasting insulin (FINS); meanwhile, patients with decreased homeostasis model assessment-β (HOMA-β) and high smoking index (SI) were higher in the large nodule group; decreased HOMA-β and high SI were independent risk factors for large nodules. Conclusions Age and eGFR < 60 ml/min/1.73m2 were independent risk factors for pulmonary nodules in patients with T2DM, and overweight may be a protective factor. Moreover, decreased islet B-cell function and smoking may contribute to the presence of PNs with a diameter of over 5 mm. |
| format | Article |
| id | doaj-art-481238048d674f3a962122c8784841be |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-481238048d674f3a962122c8784841be2025-02-02T12:28:27ZengBMCBMC Endocrine Disorders1472-68232025-01-012511810.1186/s12902-025-01857-9Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective studyJie Yang0Wenna Wang1Yizhen Lu2Chunyao Li3Shuwu Wei4Weiwei Sun5Dongzhimen Hospital, Affiliated to Beijing University of Chinese MedicineDongzhimen Hospital, Affiliated to Beijing University of Chinese MedicineDongzhimen Hospital, Affiliated to Beijing University of Chinese MedicineDongzhimen Hospital, Affiliated to Beijing University of Chinese MedicineBeijing University of Chinese MedicineDongzhimen Hospital, Affiliated to Beijing University of Chinese MedicineAbstract Objective To analyze the characteristics of pulmonary nodules (PNs) and related influencing factors in patients with type 2 diabetes mellitus (T2DM). Methods Retrospectively analyzed the clinical and biochemical characteristics of 224 patients with PNs and 488 patients with non-PNs in patients with T2DM, and compared the clinical data of 72 patients with large nodules (≥ 5 mm) and 152 patients with small nodules (< 5 mm) in the pulmonary nodules (PNs) group. Results Compared to the non-PNs group, the PNs Patients in the group had a longer duration of diabetes, higher age, serum creatinine (SCR), blood urea nitrogen (BUN) and the lower albumin (ALB) and body mass index (BMI); women, diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and estimated glomerular filtration rate (eGFR) < 60 ml/min1.73m2 were more represented in the PNs group; there were fewer patients with overweight in the PNs group. Age and eGFR < 60 ml/min/1.73m2 were independent risk factors for PNs in patients with T2DM, and overweight was associated with a reduced risk of PNs. Compared with the small nodule group, patients in the large nodule group had higher fasting blood glucose (FBG) and lower fasting insulin (FINS); meanwhile, patients with decreased homeostasis model assessment-β (HOMA-β) and high smoking index (SI) were higher in the large nodule group; decreased HOMA-β and high SI were independent risk factors for large nodules. Conclusions Age and eGFR < 60 ml/min/1.73m2 were independent risk factors for pulmonary nodules in patients with T2DM, and overweight may be a protective factor. Moreover, decreased islet B-cell function and smoking may contribute to the presence of PNs with a diameter of over 5 mm.https://doi.org/10.1186/s12902-025-01857-9Type 2 diabetes mellitusPulmonary nodulesEstimated glomerular filtration rateSize of nodulesOverweight |
| spellingShingle | Jie Yang Wenna Wang Yizhen Lu Chunyao Li Shuwu Wei Weiwei Sun Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study BMC Endocrine Disorders Type 2 diabetes mellitus Pulmonary nodules Estimated glomerular filtration rate Size of nodules Overweight |
| title | Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study |
| title_full | Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study |
| title_fullStr | Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study |
| title_full_unstemmed | Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study |
| title_short | Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study |
| title_sort | analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus a retrospective study |
| topic | Type 2 diabetes mellitus Pulmonary nodules Estimated glomerular filtration rate Size of nodules Overweight |
| url | https://doi.org/10.1186/s12902-025-01857-9 |
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