Segregated input to thalamic areas that project differently to core and shell auditory cortical fields
Summary: Perception of the environment is multimodal in nature, with sensory systems intricately interconnected. The ability to integrate multimodal sensations while preserving the distinct characteristics of each sensory modality is crucial, and the underlying mechanisms of the organization that fa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224029481 |
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| author | Tetsufumi Ito Mamiko Yamamoto Li Liu Khaleeq Ahmad Saqib Takafumi Furuyama Munenori Ono |
| author_facet | Tetsufumi Ito Mamiko Yamamoto Li Liu Khaleeq Ahmad Saqib Takafumi Furuyama Munenori Ono |
| author_sort | Tetsufumi Ito |
| collection | DOAJ |
| description | Summary: Perception of the environment is multimodal in nature, with sensory systems intricately interconnected. The ability to integrate multimodal sensations while preserving the distinct characteristics of each sensory modality is crucial, and the underlying mechanisms of the organization that facilitate this process require further elucidation. In the auditory system, although the concept of core and shell pathways is well established, the brain-wide input/output relationships of thalamic regions projecting to auditory-responsive cortical areas remain insufficiently studied, particularly in relation to non-auditory structures. In this study, we utilized functional imaging and viral tracing techniques to map the brain-wide connections of core and shell pathways. We identified three distinct shell pathways, in addition to a core pathway, each exhibiting unique associations with non-auditory structures involved in behavior, emotion, and other functions. This architecture suggests that these pathways contribute differentially to various aspects of multimodal sensory integration. |
| format | Article |
| id | doaj-art-480b38acad56410686812a9ff0ef3283 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-480b38acad56410686812a9ff0ef32832025-01-21T04:13:17ZengElsevieriScience2589-00422025-02-01282111721Segregated input to thalamic areas that project differently to core and shell auditory cortical fieldsTetsufumi Ito0Mamiko Yamamoto1Li Liu2Khaleeq Ahmad Saqib3Takafumi Furuyama4Munenori Ono5Systems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama 930-0194 Japan; Corresponding authorSystems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama 930-0194 JapanAnatomy 2, School of Medicine, Kanazawa Medical University, Uchinada 920-0265 JapanSystems Function and Morphology Laboratory, Graduate School of Innovative Life Science, University of Toyama, Toyama 930-0194 JapanPhysiology 1, School of Medicine, Kanazawa Medical University, Uchinada 920-0265, JapanPhysiology 1, School of Medicine, Kanazawa Medical University, Uchinada 920-0265, JapanSummary: Perception of the environment is multimodal in nature, with sensory systems intricately interconnected. The ability to integrate multimodal sensations while preserving the distinct characteristics of each sensory modality is crucial, and the underlying mechanisms of the organization that facilitate this process require further elucidation. In the auditory system, although the concept of core and shell pathways is well established, the brain-wide input/output relationships of thalamic regions projecting to auditory-responsive cortical areas remain insufficiently studied, particularly in relation to non-auditory structures. In this study, we utilized functional imaging and viral tracing techniques to map the brain-wide connections of core and shell pathways. We identified three distinct shell pathways, in addition to a core pathway, each exhibiting unique associations with non-auditory structures involved in behavior, emotion, and other functions. This architecture suggests that these pathways contribute differentially to various aspects of multimodal sensory integration.http://www.sciencedirect.com/science/article/pii/S2589004224029481NeuroscienceSensory neuroscience |
| spellingShingle | Tetsufumi Ito Mamiko Yamamoto Li Liu Khaleeq Ahmad Saqib Takafumi Furuyama Munenori Ono Segregated input to thalamic areas that project differently to core and shell auditory cortical fields iScience Neuroscience Sensory neuroscience |
| title | Segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| title_full | Segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| title_fullStr | Segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| title_full_unstemmed | Segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| title_short | Segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| title_sort | segregated input to thalamic areas that project differently to core and shell auditory cortical fields |
| topic | Neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224029481 |
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