A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.

The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ribose sulfamate, ML901, as a potent reaction hijacking inhi...

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Main Authors: Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Sergio Wittlin, Yawei Du, Yongbo Hu, Con Dogovski, Mina Salimimarand, Robert Griffin, Dylan England, Elisa de la Cruz, Ioanna Deni, Tomas Yeo, Anna Y Burkhard, Josefine Striepen, Kyra A Schindler, Benigno Crespo, Francisco J Gamo, Yogesh Khandokar, Craig A Hutton, Tayla Rabie, Lyn-Marié Birkholtz, Mufuliat T Famodimu, Michael J Delves, Judith Bolsher, Karin M J Koolen, Rianne van der Laak, Anna C C Aguiar, Dhelio B Pereira, Rafael V C Guido, Darren J Creek, David A Fidock, Lawrence R Dick, Stephen L Brand, Alexandra E Gould, Steven Langston, Michael D W Griffin, Leann Tilley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012429
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