Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging
Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. Antioxidants that reduce ROS production and inhibit in...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Applied Biological Chemistry |
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| Online Access: | https://doi.org/10.1186/s13765-024-00976-6 |
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| author | Seul Ki Kim Sang-Back Kim Seul Bi Lee Kang sub Kim So-Ri Son En Jin Choi Byung Chul Park Eunyoung Hong You Ah Kim Byoung Seok Moon Sullim Lee |
| author_facet | Seul Ki Kim Sang-Back Kim Seul Bi Lee Kang sub Kim So-Ri Son En Jin Choi Byung Chul Park Eunyoung Hong You Ah Kim Byoung Seok Moon Sullim Lee |
| author_sort | Seul Ki Kim |
| collection | DOAJ |
| description | Abstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. Antioxidants that reduce ROS production and inhibit inflammatory skin lesions are considered beneficial for the treatment of inflammatory skin diseases and prevention of skin aging. In this study, we evaluated the potential of Nypa fruticans (NF), which is known for its antioxidant properties, to mitigate tumor necrosis factor-alpha (TNF-α)- and interferon-gamma (IFN-γ)-induced damage in normal human epidermal keratinocytes. The major active constituents identified in NF include protocatechuic acid, hydroxybenzoic acid, procyanidin B, catechin, and epicatechin. NF significantly suppressed the production of ROS, nitric oxide (NO), and prostaglandin E2 (PGE2), while also reducing the levels of inflammatory cytokines interleukin-6 (IL-6) and interleukin-1 beta (IL-1β), which were elevated by TNF-α/IFN-γ stimulation. Furthermore, NF restored the expression of key skin barrier-related proteins such as serine peptidase inhibitor kazal type 5 (SPINK5), collagen type I alpha 1 chain (COLIA1), loricrin (LOR), aquaporin-3 (AQP3), and filaggrin (FLG). Additionally, NF significantly upregulated the expression of hyaluronan synthase (HAS) -1 and − 2 and human β-defensin (HBD) -2 and − 3, which are important for skin hydration and innate immune defense. These findings underscore the potential therapeutic applications of Nypa fruticans (NF) in mitigating oxidative stress, inflammation, skin barrier dysfunction, dehydration, and microbial imbalances. By targeting multiple pathways implicated in skin aging, NF represents a promising comprehensive approach for preserving skin health and addressing age-related dermatological conditions. Moreover, NF holds significant potential not only to alleviate the manifestations of skin aging but also to provide a basis for the development of innovative dermatological therapies. Future investigations should aim to further elucidate the clinical applications of NF in dermatology to maximize its therapeutic benefits. |
| format | Article |
| id | doaj-art-4803293247da425baefe9cb10165b70f |
| institution | Kabale University |
| issn | 2468-0842 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Applied Biological Chemistry |
| spelling | doaj-art-4803293247da425baefe9cb10165b70f2025-01-19T12:36:37ZengSpringerOpenApplied Biological Chemistry2468-08422025-01-0168111610.1186/s13765-024-00976-6Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and agingSeul Ki Kim0Sang-Back Kim1Seul Bi Lee2Kang sub Kim3So-Ri Son4En Jin Choi5Byung Chul Park6Eunyoung Hong7You Ah Kim8Byoung Seok Moon9Sullim Lee10Innovative Drug Discovery R&D Institute Pharmacology Research Center, HK inno.NIngredient R&D CenterFood Science R&D CenterCollege of Korean Medicine, Gachon UniversityDepartment of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee UniversityFood Science R&D CenterR&D ComplexHealth Food Research Center, HK Kolmar GlobalSkin&Natural products Lab. Kolmar Korea HoldingsHealth Food Research Center, HK Kolmar GlobalDepartment of Life Science, College of Bio-Nano Technology, Gachon UniversityAbstract Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. Antioxidants that reduce ROS production and inhibit inflammatory skin lesions are considered beneficial for the treatment of inflammatory skin diseases and prevention of skin aging. In this study, we evaluated the potential of Nypa fruticans (NF), which is known for its antioxidant properties, to mitigate tumor necrosis factor-alpha (TNF-α)- and interferon-gamma (IFN-γ)-induced damage in normal human epidermal keratinocytes. The major active constituents identified in NF include protocatechuic acid, hydroxybenzoic acid, procyanidin B, catechin, and epicatechin. NF significantly suppressed the production of ROS, nitric oxide (NO), and prostaglandin E2 (PGE2), while also reducing the levels of inflammatory cytokines interleukin-6 (IL-6) and interleukin-1 beta (IL-1β), which were elevated by TNF-α/IFN-γ stimulation. Furthermore, NF restored the expression of key skin barrier-related proteins such as serine peptidase inhibitor kazal type 5 (SPINK5), collagen type I alpha 1 chain (COLIA1), loricrin (LOR), aquaporin-3 (AQP3), and filaggrin (FLG). Additionally, NF significantly upregulated the expression of hyaluronan synthase (HAS) -1 and − 2 and human β-defensin (HBD) -2 and − 3, which are important for skin hydration and innate immune defense. These findings underscore the potential therapeutic applications of Nypa fruticans (NF) in mitigating oxidative stress, inflammation, skin barrier dysfunction, dehydration, and microbial imbalances. By targeting multiple pathways implicated in skin aging, NF represents a promising comprehensive approach for preserving skin health and addressing age-related dermatological conditions. Moreover, NF holds significant potential not only to alleviate the manifestations of skin aging but also to provide a basis for the development of innovative dermatological therapies. Future investigations should aim to further elucidate the clinical applications of NF in dermatology to maximize its therapeutic benefits.https://doi.org/10.1186/s13765-024-00976-6Nypa fruticansAntioxidantAnti-skin agingAnti-inflammatorySkin barrier |
| spellingShingle | Seul Ki Kim Sang-Back Kim Seul Bi Lee Kang sub Kim So-Ri Son En Jin Choi Byung Chul Park Eunyoung Hong You Ah Kim Byoung Seok Moon Sullim Lee Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging Applied Biological Chemistry Nypa fruticans Antioxidant Anti-skin aging Anti-inflammatory Skin barrier |
| title | Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging |
| title_full | Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging |
| title_fullStr | Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging |
| title_full_unstemmed | Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging |
| title_short | Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging |
| title_sort | investigating the antioxidant and anti inflammatory potential of nypa fruticans a multifaceted approach to skin protection and aging |
| topic | Nypa fruticans Antioxidant Anti-skin aging Anti-inflammatory Skin barrier |
| url | https://doi.org/10.1186/s13765-024-00976-6 |
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