Performance of a score to characterise adequate contact among the social network of persons with TB
BACKGROUND: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. The aim of this analysis was to validate a recently developed contact score that assessed settings of exposure and relationships between the case and contact. METHODS:...
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| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-12-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000012/art00005 |
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| author | M.E. Castellanos S. Zalwango T.H.T. Quach R. Kakaire L. Martínez M.H. Ebell K.K. Dobbin N. Kiwanuka C.C. Whalen |
| author_facet | M.E. Castellanos S. Zalwango T.H.T. Quach R. Kakaire L. Martínez M.H. Ebell K.K. Dobbin N. Kiwanuka C.C. Whalen |
| author_sort | M.E. Castellanos |
| collection | DOAJ |
| description | BACKGROUND: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. The aim of this analysis was to validate a recently developed contact score that assessed settings of exposure and relationships between the case and contact. METHODS: In a cross-sectional study from Kampala, Uganda, we estimated the prevalence of tuberculous infection (TBI) in social contacts of adult TB cases according to the setting and relationship domains of the contact score. We calculated the prevalence ratio (PR) for the association between contact scores (by domain) with TBI using modified Poisson regression models. RESULTS: We enrolled 955 household and community contacts from 119 TB cases. The prevalence of TBI in the social network was 52% (95% CI 48–55). The prevalence of TBI increased by quartile for both the setting score (44%, 40%, 53%, 70%; P trend <0.0001) and the relationship score (41%, 47%, 53%, 66%; P trend <0.0001). The setting score was associated with a higher prevalence of infection among children aged 5–14 years, whereas the relationship score was associated with infection in children aged 0–4 years. CONCLUSION: In urban Africa, contacts of TB with higher settings and relationship scores were more likely infected with M. tuberculosis. |
| format | Article |
| id | doaj-art-47ea8220f444447cb62cc6512be4d0ce |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-47ea8220f444447cb62cc6512be4d0ce2025-01-23T13:29:23ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-12-0111255656310.5588/ijtldopen.24.03765Performance of a score to characterise adequate contact among the social network of persons with TBM.E. Castellanos0S. Zalwango1T.H.T. Quach2R. Kakaire3L. Martínez4M.H. Ebell5K.K. Dobbin6N. Kiwanuka7C.C. Whalen8Global Health Institute, College of Public Health, University of Georgia, Athens, GA, USA;Makerere University College of Health Sciences, School of Public Health, Kampala, Uganda;Global Health Institute, College of Public Health, University of Georgia, Athens, GA, USA;Global Health Institute, College of Public Health, University of Georgia, Athens, GA, USA;Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA;Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA;Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA;Makerere University College of Health Sciences, School of Public Health, Kampala, Uganda;Global Health Institute, College of Public Health, University of Georgia, Athens, GA, USA;BACKGROUND: Transmission of Mycobacterium tuberculosis requires adequate contact between an infectious case and a susceptible host. The aim of this analysis was to validate a recently developed contact score that assessed settings of exposure and relationships between the case and contact. METHODS: In a cross-sectional study from Kampala, Uganda, we estimated the prevalence of tuberculous infection (TBI) in social contacts of adult TB cases according to the setting and relationship domains of the contact score. We calculated the prevalence ratio (PR) for the association between contact scores (by domain) with TBI using modified Poisson regression models. RESULTS: We enrolled 955 household and community contacts from 119 TB cases. The prevalence of TBI in the social network was 52% (95% CI 48–55). The prevalence of TBI increased by quartile for both the setting score (44%, 40%, 53%, 70%; P trend <0.0001) and the relationship score (41%, 47%, 53%, 66%; P trend <0.0001). The setting score was associated with a higher prevalence of infection among children aged 5–14 years, whereas the relationship score was associated with infection in children aged 0–4 years. CONCLUSION: In urban Africa, contacts of TB with higher settings and relationship scores were more likely infected with M. tuberculosis.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000012/art00005tuberculous infectiontuberculosiscontacttransmissionsocial network |
| spellingShingle | M.E. Castellanos S. Zalwango T.H.T. Quach R. Kakaire L. Martínez M.H. Ebell K.K. Dobbin N. Kiwanuka C.C. Whalen Performance of a score to characterise adequate contact among the social network of persons with TB IJTLD Open tuberculous infection tuberculosis contact transmission social network |
| title | Performance of a score to characterise adequate contact among the social network of persons with TB |
| title_full | Performance of a score to characterise adequate contact among the social network of persons with TB |
| title_fullStr | Performance of a score to characterise adequate contact among the social network of persons with TB |
| title_full_unstemmed | Performance of a score to characterise adequate contact among the social network of persons with TB |
| title_short | Performance of a score to characterise adequate contact among the social network of persons with TB |
| title_sort | performance of a score to characterise adequate contact among the social network of persons with tb |
| topic | tuberculous infection tuberculosis contact transmission social network |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000012/art00005 |
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