Disease pathogenicity in Hutchinson–Gilford progeria syndrome mice: insights from lung-associated alterations

Disease pathogenicity in Hutchinson–Gilford progeria syndrome mice: insights from lung-associated alterations

Abstract Background Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by accelerated aging, impaired growth, disrupted lipid metabolism, and reduced lifespan. Methods Prior research has primarily focused on cardiovascular manifestations, our research sheds light on...

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Main Authors: Jingjing Wang, Yuelin Guan, Yue Wang, Junyi Tan, Zhongkai Cao, Yuhan Ding, Langping Gao, Haidong Fu, Xiangjun Chen, Jianyu Lin, Ning Shen, Xudong Fu, Fangqin Wang, Jianhua Mao, Lidan Hu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Aging
Hutchinson–Gilford progeria syndrome
Lungs
Progerin
Rare diseases
Online Access:https://doi.org/10.1186/s10020-025-01165-x
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