Thalamic pleomorphic xanthoastrocytoma central nervous system World Health Organization grade 3
Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic tumor. According to the 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors, PXAs with 5 or more mitoses per 10 high-power fields are classified as CNS WHO grade 3. Imaging findings of PXA CNS WHO grade 3...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325003292 |
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| Summary: | Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic tumor. According to the 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors, PXAs with 5 or more mitoses per 10 high-power fields are classified as CNS WHO grade 3. Imaging findings of PXA CNS WHO grade 3 have rarely been reported, and thalamic cases are particularly uncommon. We present a case of thalamic PXA CNS WHO grade 3. A 71-year-old male presented with progressive right hemiparesis over three months. Magnetic resonance imaging (MRI) revealed a mass lesion in the left thalamus. Due to rapid tumor growth causing obstructive hydrocephalus, he underwent urgent craniotomy for tumor resection. Histopathology confirmed a PXA CNS WHO grade 3. Postoperatively, the patient received 54 Gy of radiation therapy in 27 fractions. His right hemiparesis persisted. He was subsequently transferred to a rehabilitation hospital. |
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| ISSN: | 1930-0433 |