Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing
We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reduc...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.81 |
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| _version_ | 1832566753672036352 |
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| author | Laura Trapani Valentina Pallottini |
| author_facet | Laura Trapani Valentina Pallottini |
| author_sort | Laura Trapani |
| collection | DOAJ |
| description | We present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced. |
| format | Article |
| id | doaj-art-47d2776b616a497eb82fc32482cd300d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-47d2776b616a497eb82fc32482cd300d2025-02-03T01:03:18ZengWileyThe Scientific World Journal1537-744X2009-01-01956457410.1100/tsw.2009.81Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during AgeingLaura Trapani0Valentina Pallottini1Department of Biology, University of Roma Tre, Roma, ItalyDepartment of Biology, University of Roma Tre, Roma, ItalyWe present here a brief description of the path that cholesterol covers from its intestinal absorption to its effect exerted on some enzyme regulation. Some mechanisms underlying hypercholesterolemia onset and, in particular, the role and the regulation of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) during adult life and during aging, have been described. In addition some pharmacological interventions to control proper HMGR regulation and, in turn, cholesterol homeostasis maintenance will be introduced.http://dx.doi.org/10.1100/tsw.2009.81 |
| spellingShingle | Laura Trapani Valentina Pallottini Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing The Scientific World Journal |
| title | Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing |
| title_full | Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing |
| title_fullStr | Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing |
| title_full_unstemmed | Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing |
| title_short | Hypercholesterolemia and 3-Hydroxy 3-Methylglutaryl Coenzyme A Reductase Regulation during Ageing |
| title_sort | hypercholesterolemia and 3 hydroxy 3 methylglutaryl coenzyme a reductase regulation during ageing |
| url | http://dx.doi.org/10.1100/tsw.2009.81 |
| work_keys_str_mv | AT lauratrapani hypercholesterolemiaand3hydroxy3methylglutarylcoenzymeareductaseregulationduringageing AT valentinapallottini hypercholesterolemiaand3hydroxy3methylglutarylcoenzymeareductaseregulationduringageing |