Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights
Wound healing process is associated with multifaceted complications and is a functional way to advance the therapeutic process. Polymeric biomaterials exhibit structural mimicry with the extracellular matrix of the tissue to be regenerated and they also avoid chronic inflammation and immunological r...
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| Format: | Article |
| Language: | English |
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IEEE
2025-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/10969627/ |
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| author | Shourya Bodla Prince Jain Anwesha Khanra Chhavi Sharma Anupam Jyoti Shiv Dutt Purohit Hemant Singh Abhijeet Singh Juhi Saxena |
| author_facet | Shourya Bodla Prince Jain Anwesha Khanra Chhavi Sharma Anupam Jyoti Shiv Dutt Purohit Hemant Singh Abhijeet Singh Juhi Saxena |
| author_sort | Shourya Bodla |
| collection | DOAJ |
| description | Wound healing process is associated with multifaceted complications and is a functional way to advance the therapeutic process. Polymeric biomaterials exhibit structural mimicry with the extracellular matrix of the tissue to be regenerated and they also avoid chronic inflammation and immunological responses. Chitosan, a biopolymer demonstrates exceptional healing properties because of its biocompatibility, biodegradability, antimicrobial nature and affinity for biomolecules. Biomaterials consisting of chitosan along with herbal extracts could be ideal for wound healing. Click chemistry can provide one of the best ways to combine these bio-actives with chitosan. Advancing wound healing strategies with artificial intelligence /machine learning approaches can be employed further to boost the clinical efficacies of bioactive-loaded chitosan composite hydrogels. This review article investigates functionalized wound dressings with special emphasis on chitosan-based hydrogels, their effects on wound healing, and advanced approaches to increase hydrogel benefits by adding bioactive substances to form nanocomposites. |
| format | Article |
| id | doaj-art-47c80098c7254a74b43cf0bd5ec7496c |
| institution | DOAJ |
| issn | 2644-1276 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-47c80098c7254a74b43cf0bd5ec7496c2025-08-20T02:41:55ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762025-01-01645045810.1109/OJEMB.2025.356238210969627Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML InsightsShourya Bodla0https://orcid.org/0009-0003-8393-3112Prince Jain1https://orcid.org/0000-0002-7950-7263Anwesha Khanra2Chhavi Sharma3https://orcid.org/0000-0003-3118-5100Anupam Jyoti4Shiv Dutt Purohit5https://orcid.org/0000-0002-1423-521XHemant Singh6Abhijeet Singh7https://orcid.org/0000-0001-5274-6080Juhi Saxena8https://orcid.org/0000-0002-4135-7466Department of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, IndiaDepartment of Mechatronics Engineering, Parul Institute of Technology, Parul University, Vadodara, IndiaDepartment of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, IndiaUniversity Centre for Research and Development, University Institute of Biotechnology, Chandigarh University, Mohali, IndiaInflammation Research Laboratory, Department of Life Science, Parul Institute of Applied Science, Parul University, Vadodara, IndiaDepartment of Biomedical Engineering and Biotechnology, Khalifa University, Abu Dhabi, United Arab EmiratesDepartment of Biological Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab EmiratesCancer Research Laboratory, Department of Biosciences, Manipal University Jaipur, Jaipur, IndiaDepartment of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, IndiaWound healing process is associated with multifaceted complications and is a functional way to advance the therapeutic process. Polymeric biomaterials exhibit structural mimicry with the extracellular matrix of the tissue to be regenerated and they also avoid chronic inflammation and immunological responses. Chitosan, a biopolymer demonstrates exceptional healing properties because of its biocompatibility, biodegradability, antimicrobial nature and affinity for biomolecules. Biomaterials consisting of chitosan along with herbal extracts could be ideal for wound healing. Click chemistry can provide one of the best ways to combine these bio-actives with chitosan. Advancing wound healing strategies with artificial intelligence /machine learning approaches can be employed further to boost the clinical efficacies of bioactive-loaded chitosan composite hydrogels. This review article investigates functionalized wound dressings with special emphasis on chitosan-based hydrogels, their effects on wound healing, and advanced approaches to increase hydrogel benefits by adding bioactive substances to form nanocomposites.https://ieeexplore.ieee.org/document/10969627/Artificial intelligencebiomimetic hydrogelsclick chemistrysustainable development goal 3wound healing |
| spellingShingle | Shourya Bodla Prince Jain Anwesha Khanra Chhavi Sharma Anupam Jyoti Shiv Dutt Purohit Hemant Singh Abhijeet Singh Juhi Saxena Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights IEEE Open Journal of Engineering in Medicine and Biology Artificial intelligence biomimetic hydrogels click chemistry sustainable development goal 3 wound healing |
| title | Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights |
| title_full | Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights |
| title_fullStr | Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights |
| title_full_unstemmed | Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights |
| title_short | Biomimetic Chitosan-Based Hydrogels for Sustainable Wound Healing With AI/ML Insights |
| title_sort | biomimetic chitosan based hydrogels for sustainable wound healing with ai x002f ml insights |
| topic | Artificial intelligence biomimetic hydrogels click chemistry sustainable development goal 3 wound healing |
| url | https://ieeexplore.ieee.org/document/10969627/ |
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