Unveiling the role of lncRNA ERDR1 in immune cell regulation
Long non-coding RNAs (lncRNAs) are a class of RNA molecules that exceed 200 nucleotides in length and lack the capacity to encode proteins. In recent years, there has been a surge of interest in lncRNA research, leading to the discovery of their diverse structures and functions. This review focused...
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004657 |
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| author | Aihua Shu Xu Tian Jie Yue Yuxia Jiang Yifei Liu |
| author_facet | Aihua Shu Xu Tian Jie Yue Yuxia Jiang Yifei Liu |
| author_sort | Aihua Shu |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are a class of RNA molecules that exceed 200 nucleotides in length and lack the capacity to encode proteins. In recent years, there has been a surge of interest in lncRNA research, leading to the discovery of their diverse structures and functions. This review focused on elucidating the regulatory roles of lncRNA erythroid differentiation regulatory 1 (Erdr1) within immune cells and its involvement in related disorders. By synthesizing findings from recent studies sourced from PubMed, this paper examined the biological functions and underlying mechanisms by which lncRNA Erdr1 influences immune cells and contributes to various diseases. Emerging research highlights that lncRNA Erdr1 exerts significant effects on the functionality of immune cells, particularly T lymphocytes (T cells), natural killer (NK) cells, and macrophages. Furthermore, Erdr1 has been implicated in the mitigation of several diseases, including acne, wound healing, osteoarthritis, melanoma, gastric cancer, obesity, and autism. Given its complex biological functions and mechanisms, Erdr1 presents itself as a promising biomarker and a potential therapeutic target for a range of immune cell-related disorders. |
| format | Article |
| id | doaj-art-47c10fd71baf40b790adb6a8f5f8d5a1 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-47c10fd71baf40b790adb6a8f5f8d5a12025-02-06T05:12:33ZengElsevierHeliyon2405-84402025-02-01113e42085Unveiling the role of lncRNA ERDR1 in immune cell regulationAihua Shu0Xu Tian1Jie Yue2Yuxia Jiang3Yifei Liu4Department of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China; Yichang Central People's Hospital, Yichang, Hubei Province, 443000, China; The Institute of Geriatric Anesthesia, China Three Gorges University, Yichang, Hubei Province, 443000, ChinaDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China; Yichang Central People's Hospital, Yichang, Hubei Province, 443000, China; The Institute of Geriatric Anesthesia, China Three Gorges University, Yichang, Hubei Province, 443000, ChinaDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China; Yichang Central People's Hospital, Yichang, Hubei Province, 443000, China; The Institute of Geriatric Anesthesia, China Three Gorges University, Yichang, Hubei Province, 443000, ChinaDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China; Yichang Central People's Hospital, Yichang, Hubei Province, 443000, China; The Institute of Geriatric Anesthesia, China Three Gorges University, Yichang, Hubei Province, 443000, ChinaDepartment of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China; Yichang Central People's Hospital, Yichang, Hubei Province, 443000, China; The Institute of Geriatric Anesthesia, China Three Gorges University, Yichang, Hubei Province, 443000, China; Corresponding author. Department of Anesthesiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443000, China.Long non-coding RNAs (lncRNAs) are a class of RNA molecules that exceed 200 nucleotides in length and lack the capacity to encode proteins. In recent years, there has been a surge of interest in lncRNA research, leading to the discovery of their diverse structures and functions. This review focused on elucidating the regulatory roles of lncRNA erythroid differentiation regulatory 1 (Erdr1) within immune cells and its involvement in related disorders. By synthesizing findings from recent studies sourced from PubMed, this paper examined the biological functions and underlying mechanisms by which lncRNA Erdr1 influences immune cells and contributes to various diseases. Emerging research highlights that lncRNA Erdr1 exerts significant effects on the functionality of immune cells, particularly T lymphocytes (T cells), natural killer (NK) cells, and macrophages. Furthermore, Erdr1 has been implicated in the mitigation of several diseases, including acne, wound healing, osteoarthritis, melanoma, gastric cancer, obesity, and autism. Given its complex biological functions and mechanisms, Erdr1 presents itself as a promising biomarker and a potential therapeutic target for a range of immune cell-related disorders.http://www.sciencedirect.com/science/article/pii/S2405844025004657Long non-coding RNAErythroid differentiation regulatory 1 (Erdr1)Immune cellsTherapeutic target |
| spellingShingle | Aihua Shu Xu Tian Jie Yue Yuxia Jiang Yifei Liu Unveiling the role of lncRNA ERDR1 in immune cell regulation Heliyon Long non-coding RNA Erythroid differentiation regulatory 1 (Erdr1) Immune cells Therapeutic target |
| title | Unveiling the role of lncRNA ERDR1 in immune cell regulation |
| title_full | Unveiling the role of lncRNA ERDR1 in immune cell regulation |
| title_fullStr | Unveiling the role of lncRNA ERDR1 in immune cell regulation |
| title_full_unstemmed | Unveiling the role of lncRNA ERDR1 in immune cell regulation |
| title_short | Unveiling the role of lncRNA ERDR1 in immune cell regulation |
| title_sort | unveiling the role of lncrna erdr1 in immune cell regulation |
| topic | Long non-coding RNA Erythroid differentiation regulatory 1 (Erdr1) Immune cells Therapeutic target |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004657 |
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