In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders

In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders

Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of the dopaminergic neurons in the substantia nigra as well as degeneration as and decreased activity in the putamen....

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Main Authors: Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Putamen
Transcriptomics
Parkinson’s disease
Hub genes
Online Access:https://doi.org/10.1186/s43042-025-00643-5
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