Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity
Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of t...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6633824 |
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| author | Nilberto Dias de Araújo Fábio Magalhães Gama Mateus de Souza Barros Thaís Lohana Pereira Ribeiro Fabíola Silva Alves Lilyane Amorim Xabregas Andréa Monteiro Tarragô Adriana Malheiro Allyson Guimarães Costa |
| author_facet | Nilberto Dias de Araújo Fábio Magalhães Gama Mateus de Souza Barros Thaís Lohana Pereira Ribeiro Fabíola Silva Alves Lilyane Amorim Xabregas Andréa Monteiro Tarragô Adriana Malheiro Allyson Guimarães Costa |
| author_sort | Nilberto Dias de Araújo |
| collection | DOAJ |
| description | Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (γδ), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent years, these cell populations have been associated with a repertoire of anti- or protumor responses and play important roles in the dynamics of solid tumors and hematological malignancies, thus, encouraging the development of new investigations in the area. This review focuses on the current knowledge regarding the role of unconventional T cell populations in the antitumor immune response in leukemia and discusses why further studies on the immunotherapeutic potential of these cells are needed. |
| format | Article |
| id | doaj-art-47bda451dfd74898a15a3b018a7292a7 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-47bda451dfd74898a15a3b018a7292a72025-02-03T01:20:48ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66338246633824Translating Unconventional T Cells and Their Roles in Leukemia Antitumor ImmunityNilberto Dias de Araújo0Fábio Magalhães Gama1Mateus de Souza Barros2Thaís Lohana Pereira Ribeiro3Fabíola Silva Alves4Lilyane Amorim Xabregas5Andréa Monteiro Tarragô6Adriana Malheiro7Allyson Guimarães Costa8Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, AM 69067-005, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, AM 69067-005, BrazilDiretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM 69050-001, BrazilDiretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM 69050-001, BrazilDiretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM 69050-001, BrazilDiretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, AM 69050-001, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, AM 69067-005, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, AM 69067-005, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas (UFAM), Manaus, AM 69067-005, BrazilRecently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (γδ), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent years, these cell populations have been associated with a repertoire of anti- or protumor responses and play important roles in the dynamics of solid tumors and hematological malignancies, thus, encouraging the development of new investigations in the area. This review focuses on the current knowledge regarding the role of unconventional T cell populations in the antitumor immune response in leukemia and discusses why further studies on the immunotherapeutic potential of these cells are needed.http://dx.doi.org/10.1155/2021/6633824 |
| spellingShingle | Nilberto Dias de Araújo Fábio Magalhães Gama Mateus de Souza Barros Thaís Lohana Pereira Ribeiro Fabíola Silva Alves Lilyane Amorim Xabregas Andréa Monteiro Tarragô Adriana Malheiro Allyson Guimarães Costa Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity Journal of Immunology Research |
| title | Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity |
| title_full | Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity |
| title_fullStr | Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity |
| title_full_unstemmed | Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity |
| title_short | Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity |
| title_sort | translating unconventional t cells and their roles in leukemia antitumor immunity |
| url | http://dx.doi.org/10.1155/2021/6633824 |
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