HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast
Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coinc...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2014/310829 |
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| author | Katsumi Kito Toshiharu Maeda Keiko Ninomiya Atsuro Sugita Teiri Sagawa Kinya Matsuoka Kousei Kinoshita Naoki Hyodo Nagisa Morita Keizo Furuya |
| author_facet | Katsumi Kito Toshiharu Maeda Keiko Ninomiya Atsuro Sugita Teiri Sagawa Kinya Matsuoka Kousei Kinoshita Naoki Hyodo Nagisa Morita Keizo Furuya |
| author_sort | Katsumi Kito |
| collection | DOAJ |
| description | Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma. |
| format | Article |
| id | doaj-art-47b2b686735d4092853b0bd2761d3ebb |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-47b2b686735d4092853b0bd2761d3ebb2025-02-03T01:12:18ZengWileyCase Reports in Pathology2090-67812090-679X2014-01-01201410.1155/2014/310829310829HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the BreastKatsumi Kito0Toshiharu Maeda1Keiko Ninomiya2Atsuro Sugita3Teiri Sagawa4Kinya Matsuoka5Kousei Kinoshita6Naoki Hyodo7Nagisa Morita8Keizo Furuya9Department of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Surgery, Ehime Prefectural Central Hospital, Matsuyama 790-0024, JapanDepartment of Surgery, Ehime Prefectural Central Hospital, Matsuyama 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanDepartment of Pathology, Ehime Prefectural Central Hospital, 83 Kasuga-cho, Matsuyama, Ehime 790-0024, JapanApocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.http://dx.doi.org/10.1155/2014/310829 |
| spellingShingle | Katsumi Kito Toshiharu Maeda Keiko Ninomiya Atsuro Sugita Teiri Sagawa Kinya Matsuoka Kousei Kinoshita Naoki Hyodo Nagisa Morita Keizo Furuya HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast Case Reports in Pathology |
| title | HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast |
| title_full | HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast |
| title_fullStr | HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast |
| title_full_unstemmed | HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast |
| title_short | HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast |
| title_sort | her2 positive metaplastic spindle cell carcinoma associated with synchronous bilateral apocrine carcinoma of the breast |
| url | http://dx.doi.org/10.1155/2014/310829 |
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