Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru
Abstract Introduction Chronic exposure to pesticides causes various adverse health effects, mainly at a neurological level. However, there is little evidence focused on liver tissue injury and transaminase activity as indicators of effect. Methods A cross-sectional study was designed based on medica...
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BMC
2025-01-01
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| Series: | Journal of Occupational Medicine and Toxicology |
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| Online Access: | https://doi.org/10.1186/s12995-025-00450-z |
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| author | Emily Ortiz-Delgado Guido Bendezu-Quispe Fernando Soncco-Llulluy Jair Li Jaime Rosales-Rimache |
| author_facet | Emily Ortiz-Delgado Guido Bendezu-Quispe Fernando Soncco-Llulluy Jair Li Jaime Rosales-Rimache |
| author_sort | Emily Ortiz-Delgado |
| collection | DOAJ |
| description | Abstract Introduction Chronic exposure to pesticides causes various adverse health effects, mainly at a neurological level. However, there is little evidence focused on liver tissue injury and transaminase activity as indicators of effect. Methods A cross-sectional study was designed based on medical-occupational records of workers from an agro-export company in Peru to associate the levels of butyrylcholinesterase (BChE) transaminases (ALT and AST). Occupational medical records were reviewed to obtain demographic and occupational information and laboratory values of BChE activity and transaminases. Results We evaluated 459 records, and 69.9% were men. The mean age was 34.9 ± 11.5 years. BChE, ALT, and AST levels were 6238.8 ± 709.1 U/l, 34.4 ± 12.5 U/l, and 22.4 ± 8.5 U/l, respectively. The proportion of inhibited BCHE and elevated transaminase levels was 15.3% and 21.6%, respectively. We found a significant association between BChE inhibition and elevation of transaminases (AST: PR = 0.798, 95%CI: 0.716–0.889; ALT: PR = 0.419, 95%CI: 0.239–0.736). Conclusion The potential usefulness of transaminases is shown as a biomarker of exposure and monitoring in occupational health programs for the agro-industry. |
| format | Article |
| id | doaj-art-47ae32dd951c44c1a5b446a434ac9739 |
| institution | Kabale University |
| issn | 1745-6673 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj-art-47ae32dd951c44c1a5b446a434ac97392025-01-19T12:44:01ZengBMCJournal of Occupational Medicine and Toxicology1745-66732025-01-012011710.1186/s12995-025-00450-zRelationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from PeruEmily Ortiz-Delgado0Guido Bendezu-Quispe1Fernando Soncco-Llulluy2Jair Li3Jaime Rosales-Rimache4Escuela de Tecnología Médica, Universidad Alas PeruanasEscuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias AplicadasCarrera de Medicina, Universidad Científica del SurFacultad de Tecnología Médica, Universidad Nacional Federico VillarrealCarrera de Medicina, Universidad ContinentalAbstract Introduction Chronic exposure to pesticides causes various adverse health effects, mainly at a neurological level. However, there is little evidence focused on liver tissue injury and transaminase activity as indicators of effect. Methods A cross-sectional study was designed based on medical-occupational records of workers from an agro-export company in Peru to associate the levels of butyrylcholinesterase (BChE) transaminases (ALT and AST). Occupational medical records were reviewed to obtain demographic and occupational information and laboratory values of BChE activity and transaminases. Results We evaluated 459 records, and 69.9% were men. The mean age was 34.9 ± 11.5 years. BChE, ALT, and AST levels were 6238.8 ± 709.1 U/l, 34.4 ± 12.5 U/l, and 22.4 ± 8.5 U/l, respectively. The proportion of inhibited BCHE and elevated transaminase levels was 15.3% and 21.6%, respectively. We found a significant association between BChE inhibition and elevation of transaminases (AST: PR = 0.798, 95%CI: 0.716–0.889; ALT: PR = 0.419, 95%CI: 0.239–0.736). Conclusion The potential usefulness of transaminases is shown as a biomarker of exposure and monitoring in occupational health programs for the agro-industry.https://doi.org/10.1186/s12995-025-00450-zButyrylcholinesteraseTransaminasesAlanine TransaminaseAspartate AminotransferasesPesticidesPeru |
| spellingShingle | Emily Ortiz-Delgado Guido Bendezu-Quispe Fernando Soncco-Llulluy Jair Li Jaime Rosales-Rimache Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru Journal of Occupational Medicine and Toxicology Butyrylcholinesterase Transaminases Alanine Transaminase Aspartate Aminotransferases Pesticides Peru |
| title | Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru |
| title_full | Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru |
| title_fullStr | Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru |
| title_full_unstemmed | Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru |
| title_short | Relationship between butyrylcholinesterase activity and hepatic transaminases: a cross-sectional study in agricultural workers from Peru |
| title_sort | relationship between butyrylcholinesterase activity and hepatic transaminases a cross sectional study in agricultural workers from peru |
| topic | Butyrylcholinesterase Transaminases Alanine Transaminase Aspartate Aminotransferases Pesticides Peru |
| url | https://doi.org/10.1186/s12995-025-00450-z |
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