A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments
Environmental pollutants including ultrafine particulate matter (UFPs) and adverse meteorological conditions pose significant public health impacts, particularly affecting respiratory health. This study aims to elucidate the synergistic effects of cold-humid conditions and UFPs exposure on respirato...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017147 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590947954720768 |
|---|---|
| author | Ziyu Shu Shuo Qing Xu Yang Ping Ma Yang Wu Baizhan Li Fangxin Fang Runming Yao |
| author_facet | Ziyu Shu Shuo Qing Xu Yang Ping Ma Yang Wu Baizhan Li Fangxin Fang Runming Yao |
| author_sort | Ziyu Shu |
| collection | DOAJ |
| description | Environmental pollutants including ultrafine particulate matter (UFPs) and adverse meteorological conditions pose significant public health impacts, particularly affecting respiratory health. This study aims to elucidate the synergistic effects of cold-humid conditions and UFPs exposure on respiratory health, utilizing Carbon Black Nanoparticles (CB-NPs) as surrogates for UFPs. Through comprehensive lung function tests, histopathological examinations, and biomarker analyses, this research focuses on the modulation of oxidative stress signaling pathways and NF-κB activation. Male Balb/c mice were exposed to specific concentrations of CB-NPs (30–50 nm in diameter, 0.184 mg/(kg·day)) in a controlled environmental chamber mimicking cold (10°C/14°C) and humid (90 % RH) conditions over three weeks. The results indicate that exposure to CB-NPs alone increased lung function, oxidative stress (ROS, GSH, MDA), inflammation (IL-6, TNF-α, IL-1β), apoptosis (Caspase 3, Caspase 8, Caspase 9), and histopathological alterations in lung tissue. Furthermore, these effects were notably more severe under combined exposure with cold-humid conditions. These results suggest that the adverse effects of pollutants are not solely concentration-dependent but are exacerbated by specific environmental contexts. It is evident that Vitamin E (100 mg/kg/day) can attenuate these adverse effects, underscoring its potential as a protective agent against environmental stressor-induced air pollutants and cold humid conditions. Our findings suggest that the synergistic effects of environmental factors and pollutant exposure significantly impact respiratory health, providing valuable insights for the design of healthier indoor environments and the development of strategies to mitigate these risks. |
| format | Article |
| id | doaj-art-479718b1d16d461a834ca07541f8874a |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-479718b1d16d461a834ca07541f8874a2025-01-23T05:25:56ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117638A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environmentsZiyu Shu0Shuo Qing1Xu Yang2Ping Ma3Yang Wu4Baizhan Li5Fangxin Fang6Runming Yao7Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, ChinaJoint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, ChinaKey Laboratory of Environmental Related Diseases and One Health, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, PR China; Institute of Eastern-Himalaya Biodiversity Research, Dali University, Dali 671003, ChinaKey Laboratory of Environmental Related Diseases and One Health, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, PR ChinaKey Laboratory of Environmental Related Diseases and One Health, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, PR ChinaJoint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, ChinaDepartment of Earth Science and Engineering, Imperial College London, London SW7 2AZ, UKJoint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; School of the Built Environment, University of Reading, Reading RG6 6DB, UK; Corresponding author at: Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China.Environmental pollutants including ultrafine particulate matter (UFPs) and adverse meteorological conditions pose significant public health impacts, particularly affecting respiratory health. This study aims to elucidate the synergistic effects of cold-humid conditions and UFPs exposure on respiratory health, utilizing Carbon Black Nanoparticles (CB-NPs) as surrogates for UFPs. Through comprehensive lung function tests, histopathological examinations, and biomarker analyses, this research focuses on the modulation of oxidative stress signaling pathways and NF-κB activation. Male Balb/c mice were exposed to specific concentrations of CB-NPs (30–50 nm in diameter, 0.184 mg/(kg·day)) in a controlled environmental chamber mimicking cold (10°C/14°C) and humid (90 % RH) conditions over three weeks. The results indicate that exposure to CB-NPs alone increased lung function, oxidative stress (ROS, GSH, MDA), inflammation (IL-6, TNF-α, IL-1β), apoptosis (Caspase 3, Caspase 8, Caspase 9), and histopathological alterations in lung tissue. Furthermore, these effects were notably more severe under combined exposure with cold-humid conditions. These results suggest that the adverse effects of pollutants are not solely concentration-dependent but are exacerbated by specific environmental contexts. It is evident that Vitamin E (100 mg/kg/day) can attenuate these adverse effects, underscoring its potential as a protective agent against environmental stressor-induced air pollutants and cold humid conditions. Our findings suggest that the synergistic effects of environmental factors and pollutant exposure significantly impact respiratory health, providing valuable insights for the design of healthier indoor environments and the development of strategies to mitigate these risks.http://www.sciencedirect.com/science/article/pii/S0147651324017147Indoor air qualityCold-Humid environmentsUltrafine ParticulateOxidative stressNF-κB activationVitamin E |
| spellingShingle | Ziyu Shu Shuo Qing Xu Yang Ping Ma Yang Wu Baizhan Li Fangxin Fang Runming Yao A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments Ecotoxicology and Environmental Safety Indoor air quality Cold-Humid environments Ultrafine Particulate Oxidative stress NF-κB activation Vitamin E |
| title | A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| title_full | A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| title_fullStr | A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| title_full_unstemmed | A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| title_short | A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| title_sort | molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments |
| topic | Indoor air quality Cold-Humid environments Ultrafine Particulate Oxidative stress NF-κB activation Vitamin E |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017147 |
| work_keys_str_mv | AT ziyushu amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT shuoqing amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT xuyang amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT pingma amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT yangwu amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT baizhanli amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT fangxinfang amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT runmingyao amoleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT ziyushu moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT shuoqing moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT xuyang moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT pingma moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT yangwu moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT baizhanli moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT fangxinfang moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments AT runmingyao moleculartoxicologicalstudytoexplorepotentialhealthrisksassociatedwithultrafineparticleexposureincoldandhumidindoorenvironments |