Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure
Introduction We aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure. Material and methods Using a large electronic medical record-based cohort of diabetes in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-10-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Aspartate-aminotransferase-to-alanine-aminotransferase-ratio-and-short-term-prognosis,184153,0,2.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584856997986304 |
|---|---|
| author | Dan Liu Li Liu Nan Li Yiling Zhou Hongmei Huang Jidong He Heling Yao Xiangyang Chen Xiaochi Tang Miye Wang Ying Qi Si Wang Ye Zhu Haoming Tian Zhenmei An Sheyu Li |
| author_facet | Dan Liu Li Liu Nan Li Yiling Zhou Hongmei Huang Jidong He Heling Yao Xiangyang Chen Xiaochi Tang Miye Wang Ying Qi Si Wang Ye Zhu Haoming Tian Zhenmei An Sheyu Li |
| author_sort | Dan Liu |
| collection | DOAJ |
| description | Introduction
We aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure.
Material and methods
Using a large electronic medical record-based cohort of diabetes in China (WECODe), we gathered data on non-surgical hospitalized patients with type 2 diabetes and heart failure from 2011 to 2019. Baseline AST/ALT ratio was calculated. The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. A multivariable Cox proportional regression model was utilized to evaluate the association between the AST/ALT ratio and outcomes.
Results
This retrospective cohort included 8,073 patients (39.4% women) with type 2 diabetes hospitalized for heart failure. The median age was 71 years. Higher AST/ALT ratio was associated with higher risks of poor endpoints (with per standard deviation increment in AST/ALT ratio, for death within 30 days after discharge: adjusted hazard ratio [HR], 1.35, 95% confidence interval [CI], 1.21 to 1.50; for composite cardiac events: HR, 1.18, 95% CI: 1.06 to 1.31). Compared to patients in the lowest quartile for the AST/ALT ratio, those in the highest quartile have elevated risk of death within 30 days after discharge and major systemic infection (HRs [95% CIs]: 1.61 [1.18 to 2.19] and 1.28 [1.06 to 1.56], respectively). Subgroup analyses and sensitivity analyses confirmed the robustness of the findings.
Conclusions
Type 2 diabetes patients hospitalized for heart failure with the AST/ALT ratio in the highest quartile face a poor short-term prognosis. |
| format | Article |
| id | doaj-art-4778f96390d64e0296c83b5119eeef9f |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-4778f96390d64e0296c83b5119eeef9f2025-01-27T10:44:30ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-10-012051416142510.5114/aoms/184153184153Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failureDan Liu0Li Liu1Nan Li2Yiling Zhou3Hongmei Huang4Jidong He5Heling Yao6Xiangyang Chen7Xiaochi Tang8Miye Wang9Ying Qi10Si Wang11Ye Zhu12Haoming Tian13Zhenmei An14Sheyu Li15Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, Second People’s Hospital of Ya’an City, ChinaDepartment of Informatics, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, The First People’s Hospital of Shuangliu District, ChinaDepartment of Endocrinology and Metabolism, Second People’s Hospital of Ya’an City, ChinaDepartment of Endocrinology and Metabolism, Second People’s Hospital of Ya’an City, ChinaDepartment of Endocrinology and Metabolism, The First People’s Hospital of Shuangliu District, ChinaDepartment of Endocrinology and Metabolism, The First People’s Hospital of Shuangliu District, ChinaDepartment of Informatics, West China Hospital, Sichuan University, ChinaWest China School of Medicine, Sichuan University, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, ChinaDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, ChinaIntroduction We aimed to explore the prognostic value of the aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio in non-surgical patients with type 2 diabetes hospitalized for heart failure. Material and methods Using a large electronic medical record-based cohort of diabetes in China (WECODe), we gathered data on non-surgical hospitalized patients with type 2 diabetes and heart failure from 2011 to 2019. Baseline AST/ALT ratio was calculated. The primary outcomes were all-cause death within 30 days after discharge, composite cardiac events, major acute kidney injury, and major systemic infection. A multivariable Cox proportional regression model was utilized to evaluate the association between the AST/ALT ratio and outcomes. Results This retrospective cohort included 8,073 patients (39.4% women) with type 2 diabetes hospitalized for heart failure. The median age was 71 years. Higher AST/ALT ratio was associated with higher risks of poor endpoints (with per standard deviation increment in AST/ALT ratio, for death within 30 days after discharge: adjusted hazard ratio [HR], 1.35, 95% confidence interval [CI], 1.21 to 1.50; for composite cardiac events: HR, 1.18, 95% CI: 1.06 to 1.31). Compared to patients in the lowest quartile for the AST/ALT ratio, those in the highest quartile have elevated risk of death within 30 days after discharge and major systemic infection (HRs [95% CIs]: 1.61 [1.18 to 2.19] and 1.28 [1.06 to 1.56], respectively). Subgroup analyses and sensitivity analyses confirmed the robustness of the findings. Conclusions Type 2 diabetes patients hospitalized for heart failure with the AST/ALT ratio in the highest quartile face a poor short-term prognosis.https://www.archivesofmedicalscience.com/Aspartate-aminotransferase-to-alanine-aminotransferase-ratio-and-short-term-prognosis,184153,0,2.htmlliver functionheart failuretype 2 diabeteshospitalized patientsprognosis |
| spellingShingle | Dan Liu Li Liu Nan Li Yiling Zhou Hongmei Huang Jidong He Heling Yao Xiangyang Chen Xiaochi Tang Miye Wang Ying Qi Si Wang Ye Zhu Haoming Tian Zhenmei An Sheyu Li Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure Archives of Medical Science liver function heart failure type 2 diabetes hospitalized patients prognosis |
| title | Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| title_full | Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| title_fullStr | Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| title_full_unstemmed | Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| title_short | Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| title_sort | aspartate aminotransferase to alanine aminotransferase ratio and short term prognosis of patients with type 2 diabetes hospitalized for heart failure |
| topic | liver function heart failure type 2 diabetes hospitalized patients prognosis |
| url | https://www.archivesofmedicalscience.com/Aspartate-aminotransferase-to-alanine-aminotransferase-ratio-and-short-term-prognosis,184153,0,2.html |
| work_keys_str_mv | AT danliu aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT liliu aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT nanli aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT yilingzhou aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT hongmeihuang aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT jidonghe aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT helingyao aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT xiangyangchen aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT xiaochitang aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT miyewang aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT yingqi aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT siwang aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT yezhu aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT haomingtian aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT zhenmeian aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure AT sheyuli aspartateaminotransferasetoalanineaminotransferaseratioandshorttermprognosisofpatientswithtype2diabeteshospitalizedforheartfailure |