Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes

Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes

ABSTRACT The two most extensively studied cannabinoids, cannabidiol (CBD) and delta‐9‐tetrahydrocannabinol (THC), are used for myriad conditions. THC is predominantly eliminated via the cytochromes P450 (CYPs), whereas CBD is eliminated through both CYPs and UDP‐glucuronosyltransferases (UGTs). The...

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Bibliographic Details
Main Authors: Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical and Translational Science
Subjects:
cannabidiol
cannabinoids
delta‐9‐tetrahydrocannabinol
metabolites
PBPK
pharmacokinetics
Online Access:https://doi.org/10.1111/cts.70119
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