Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

Abstract Breast cancer remains the most prevalent malignancy among women globally, with its complexity linked to genetic variations and metabolic alterations within tumor cells. This study investigates the role of fumarate hydratase (FH), a key enzyme in the tricarboxylic acid (TCA) cycle, in breast...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shyng-Shiou F. Yuan, Anupama Vadhan, Hieu D. H. Nguyen, Pang-Yu Chen, Chih-Huang Tseng, Ching-Hu Wu, Yu-Chieh Chen, Yi-Chia Wu, Stephen Chu‐Sung Hu, Steven Lo, Ming-Feng Hou, Yen-Yun Wang
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	Cancer & Metabolism
Online Access:	https://doi.org/10.1186/s40170-025-00397-z
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure
by: Andrew Roe, et al.
Published: (2025-07-01)

Fumarate hydratase-deficient renal cell carcinoma complicated with liver metastasis: case report
by: Hanmin Chen, et al.
Published: (2024-11-01)

Fumarate hydratase in cancer research: scientific trends and findings over 22 years
by: Cem Yalaza, et al.
Published: (2025-05-01)

Fumarate hydratase-deficient renal cell carcinoma: A case report and review of literature
by: Mingyu Ma, et al.
Published: (2025-05-01)

High-intensity focused ultrasound ablation in the treatment of fumarate hydratase-deficient uterine leiomyoma
by: Luyao Zhang, et al.
Published: (2024-12-01)

Morphological analysis of peritoneal fluid in fumarate hydratase deficiency-associated renal cell carcinoma: a case report
by: Yingying Du, et al.
Published: (2025-07-01)

Fumarate Hydratase-Deficient Renal Cell Carcinoma—A Clinicopathological Study of a Series of 11 Cases
by: Aswathy A. Menon, et al.
Published: (2024-12-01)

Quadruple Primary Malignancies over 2 Years with Germline Mutation in Krebs Cycle Enzyme Gene Fumarate Hydratase
by: Solaleh Aminian, et al.
Published: (2024-01-01)

An octad of fumarate hydratase-deficient uterine leiomyomas: Case series with review of literature from a single institution
by: Nishtha Batra, et al.
Published: (2025-01-01)

Complete response to fifth-line anti-PD-1 rechallenge in fumarate hydratase-mutated papillary renal cell carcinoma
by: Isabella Portugal, et al.
Published: (2024-11-01)

Hereditary leiomyomatosis and renal cell cancer (HLRCC), pheochromocytoma (PCC)/paraganglioma (PGL) and germline fumarate hydratase (FH) variants
by: John J Orrego, et al.
Published: (2024-12-01)

Association between fumarate hydratase variant subtypes and the risk of HLRCC-associated renal cell carcinoma: systematic review and meta-analysis
by: Han Wang, et al.
Published: (2025-07-01)

Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways
by: Jiang Z, et al.
Published: (2025-04-01)

Reprogramming of the Aurantinin Polyketide Assembly Line to Synthesize Auritriacids by Excising an Atypical Enoyl‐CoA Hydratase Domain
by: Dacheng Wang, et al.
Published: (2024-09-01)

The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells
by: Weiwei Wang, et al.
Published: (2025-05-01)

Dissecting the biophysical mechanisms of oleate hydratase association with membranes
by: William A. Lathram, et al.
Published: (2025-01-01)

Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation
by: Humaira Rafiq, et al.
Published: (2025-05-01)

Independent evolution of oleate hydratase clades in Bacillales reflects molecular convergence
by: Robert J. Neff, et al.
Published: (2024-12-01)

Expanding the Clinical and Genetic Spectrum of Mitochondrial Short‐Chain Enoyl‐CoA Hydratase 1 Deficiency: Insights From Two Unrelated Chinese Families
by: Jihua Wu, et al.
Published: (2025-04-01)

Structural and biochemical mechanism of short-chain enoyl-CoA hydratase (ECHS1) substrate recognition
by: Gengchen Su, et al.
Published: (2025-04-01)

Metabolic Outcomes of Changing From Rilpivirine/Tenofovir Disoproxil Fumarate/Emtricitabine to Rilpivirine/Tenofovir Alafenamide/Emtricitabine: A Longitudinal Study
by: Ping‐Feng Wu, et al.
Published: (2024-12-01)

Overexpression and characterization of two types of nitrile hydratases from Rhodococcus rhodochrous J1.
by: Yao Lan, et al.
Published: (2017-01-01)

Beclometasone Dipropionate/Formoterol Fumarate is Similarly Effective to Budesonide/Formoterol Fumarate in Chinese Patients with COPD: The FORSYYN Double-Blind, Randomised Study
by: Fuqiang Wen, et al.
Published: (2024-12-01)

The Oncogenic Burden of Obesity: Mechanistic Links Between Adiposity and Gastrointestinal Cancers—A Comprehensive Narrative Review
by: Felicia Lee, et al.
Published: (2025-06-01)

Stem Cells and Nuclear Reprogramming
by: Fuliang Du, et al.
Published: (2011-01-01)

The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
by: Yao Fong, et al.
Published: (2014-01-01)

IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment
by: Gilbert Aaron Lee, et al.
Published: (2025-03-01)

Tailoring Fumaric Acid Delivery: The Role of Surfactant-Enhanced Solid Lipid Microparticles via Spray-Congealing
by: Yen-Chiu Tsai, et al.
Published: (2024-10-01)

Farmacoterapia para dejar de fumar
by: Javier Matías Saimovici
Published: (2025-04-01)

Study of the radioprotective properties of fumaric acid and 3-hydroxypyridine fumarate under the action of ionizing radiation on human cells
by: P. S. Kuptsova, et al.
Published: (2023-04-01)

An Exploratory Pharmacogenetic Pilot Study of Two Reverse Transcriptase Inhibitors, Tenofovir Alafenamide Fumarate and Tenofovir Disoproxil Fumarate
by: Derek E. Murrell, et al.
Published: (2025-05-01)

Lymphocyte dynamics in patients with multiple sclerosis who were treated with dimethyl fumarate and subsequently switched to diroximel fumarate
by: Shauna M. Gales, et al.
Published: (2025-06-01)

Differences in the profile of cytokine expression induced by implantation of oncogenic and non-oncogenic millipore filters
by: E. Yu. Rybalkina, et al.
Published: (2019-11-01)

KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation
by: Shenyu Sun, et al.
Published: (2025-07-01)

Decoding oncogenic secrets of regulator of chromosome condensation 1: A breakthrough mechanistic evidence from breast and lung cancer models
by: Mohamed El-Tanani, et al.
Published: (2025-01-01)

Decoding oncogenic secrets of regulator of chromosome condensation 1: A breakthrough mechanistic evidence from breast and lung cancer models.
by: Mohamed El-Tanani, et al.
Published: (2025-01-01)

Simultaneous and sequential enzymatic cascades for asymmetric synthesis of chiral beta-hydroxyamide derivatives promoted by alcohol dehydrogenases and nitrile hydratases
by: Everton A. Tordato, et al.
Published: (2024-12-01)

Post-translational modifications and the reprogramming of tumor metabolism
by: Yuqing Hu, et al.
Published: (2025-05-01)

Effect of Diroximel Fumarate on gut dysbiosis and neuroinflammation
by: Sudhir Kumar Yadav, Ph.D., et al.
Published: (2025-07-01)

An oncogene regulating chromatin favors response to immunotherapy<subtitle>Oncogene CHAF1A and immunotherapy outcomes</subtitle>
by: Leqian Ying, et al.
Published: (2024-12-01)