Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment
Effective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth. We propose that “neural-like cells” may be useful for the protection of peripheral nerve destructions. Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/941625 |
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| author | Shi-lei Guo Zhi-ying Zhang Yan Xu Yun-xia Zhi Chang-jie Han Yu-hao Zhou Fang Liu Hai-yan Lin Chuan-sen Zhang |
| author_facet | Shi-lei Guo Zhi-ying Zhang Yan Xu Yun-xia Zhi Chang-jie Han Yu-hao Zhou Fang Liu Hai-yan Lin Chuan-sen Zhang |
| author_sort | Shi-lei Guo |
| collection | DOAJ |
| description | Effective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth. We propose that “neural-like cells” may be useful for the protection of peripheral nerve destructions. Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions, and improve recovery. But the mechanism of neural-like cells in the peripheral nerve is still unclear. In this study, bone marrow-derived neural-like cells were used as seed cells. The cells were injected into the distal end of severed rabbit peripheral nerves that were no longer integrated with the central nervous system. Electromyography (EMG), immunohistochemistry, and transmission electron microscopy (TEM) were employed to analyze the development of the cells in the peripheral nerve environment. The CMAP amplitude appeared during the 5th week following surgery, at which time morphological characteristics of myelinated nerve fiber formation were observed. Bone marrow-derived neural-like cells could protect the disintegration and destruction of the injured peripheral nerve. |
| format | Article |
| id | doaj-art-476a3a28978c4fae84494bb365f0eedb |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-476a3a28978c4fae84494bb365f0eedb2025-02-03T05:53:44ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/941625941625Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in MicroenvironmentShi-lei Guo0Zhi-ying Zhang1Yan Xu2Yun-xia Zhi3Chang-jie Han4Yu-hao Zhou5Fang Liu6Hai-yan Lin7Chuan-sen Zhang8Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaNanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaDepartment of Health Statistics, The Second Military Medical University, Shanghai 200433, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaRegenerative Medicine Center, The Second Military Medical University, Shanghai 200433, ChinaEffective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth. We propose that “neural-like cells” may be useful for the protection of peripheral nerve destructions. Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions, and improve recovery. But the mechanism of neural-like cells in the peripheral nerve is still unclear. In this study, bone marrow-derived neural-like cells were used as seed cells. The cells were injected into the distal end of severed rabbit peripheral nerves that were no longer integrated with the central nervous system. Electromyography (EMG), immunohistochemistry, and transmission electron microscopy (TEM) were employed to analyze the development of the cells in the peripheral nerve environment. The CMAP amplitude appeared during the 5th week following surgery, at which time morphological characteristics of myelinated nerve fiber formation were observed. Bone marrow-derived neural-like cells could protect the disintegration and destruction of the injured peripheral nerve.http://dx.doi.org/10.1155/2015/941625 |
| spellingShingle | Shi-lei Guo Zhi-ying Zhang Yan Xu Yun-xia Zhi Chang-jie Han Yu-hao Zhou Fang Liu Hai-yan Lin Chuan-sen Zhang Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment Stem Cells International |
| title | Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment |
| title_full | Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment |
| title_fullStr | Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment |
| title_full_unstemmed | Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment |
| title_short | Bone Marrow-Derived, Neural-Like Cells Have the Characteristics of Neurons to Protect the Peripheral Nerve in Microenvironment |
| title_sort | bone marrow derived neural like cells have the characteristics of neurons to protect the peripheral nerve in microenvironment |
| url | http://dx.doi.org/10.1155/2015/941625 |
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