Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target
Immunological disorders, increased oxidative stress, and damage to the epithelial barrier play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/6665697 |
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| author | Anna Socha-Banasiak Patrycja Sputa-Grzegrzółka Jędrzej Grzegrzółka Krzysztof Pacześ Piotr Dzięgiel Beata Sordyl Hanna Romanowicz Elżbieta Czkwianianc |
| author_facet | Anna Socha-Banasiak Patrycja Sputa-Grzegrzółka Jędrzej Grzegrzółka Krzysztof Pacześ Piotr Dzięgiel Beata Sordyl Hanna Romanowicz Elżbieta Czkwianianc |
| author_sort | Anna Socha-Banasiak |
| collection | DOAJ |
| description | Immunological disorders, increased oxidative stress, and damage to the epithelial barrier play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological drugs that selectively affect individual components of the inflammatory cascade. However, administering the medicines currently available does not always result in obtaining and maintaining remission, and it may also lead to the development of resistance to a given agent over time. Metallothioneins (MTs) belong to the group of low molecular weight proteins, which, among others, regulate the inflammation and homeostasis of heavy metals as well as participating in the regulation of the intensity of oxidative stress. The results of the studies conducted so far do not clearly indicate the role of MTs in the process of inflammation in patients with IBD. However, there are reports that suggest the possibility of using MTs as a potential target in the treatment of this group of patients. |
| format | Article |
| id | doaj-art-476642da050948feb57bcc6f3578165e |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-476642da050948feb57bcc6f3578165e2025-02-03T05:51:11ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/66656976665697Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy TargetAnna Socha-Banasiak0Patrycja Sputa-Grzegrzółka1Jędrzej Grzegrzółka2Krzysztof Pacześ3Piotr Dzięgiel4Beata Sordyl5Hanna Romanowicz6Elżbieta Czkwianianc7Department of Gastroenterology, Allergology and Pediatrics, Polish Mother’s Memorial Hospital-Research Institute, Lodz 93-338, PolandDivision of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-367, PolandDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-367, PolandDepartment of Gastroenterology, Allergology and Pediatrics, Polish Mother’s Memorial Hospital-Research Institute, Lodz 93-338, PolandDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-367, PolandDepartment of Gastroenterology, Allergology and Pediatrics, Polish Mother’s Memorial Hospital-Research Institute, Lodz 93-338, PolandDepartment of Pathology, Polish Mother's Memorial Hospital-Research Institute, Lodz 93-338, PolandDepartment of Gastroenterology, Allergology and Pediatrics, Polish Mother’s Memorial Hospital-Research Institute, Lodz 93-338, PolandImmunological disorders, increased oxidative stress, and damage to the epithelial barrier play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological drugs that selectively affect individual components of the inflammatory cascade. However, administering the medicines currently available does not always result in obtaining and maintaining remission, and it may also lead to the development of resistance to a given agent over time. Metallothioneins (MTs) belong to the group of low molecular weight proteins, which, among others, regulate the inflammation and homeostasis of heavy metals as well as participating in the regulation of the intensity of oxidative stress. The results of the studies conducted so far do not clearly indicate the role of MTs in the process of inflammation in patients with IBD. However, there are reports that suggest the possibility of using MTs as a potential target in the treatment of this group of patients.http://dx.doi.org/10.1155/2021/6665697 |
| spellingShingle | Anna Socha-Banasiak Patrycja Sputa-Grzegrzółka Jędrzej Grzegrzółka Krzysztof Pacześ Piotr Dzięgiel Beata Sordyl Hanna Romanowicz Elżbieta Czkwianianc Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target Canadian Journal of Gastroenterology and Hepatology |
| title | Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target |
| title_full | Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target |
| title_fullStr | Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target |
| title_full_unstemmed | Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target |
| title_short | Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target |
| title_sort | metallothioneins in inflammatory bowel diseases importance in pathogenesis and potential therapy target |
| url | http://dx.doi.org/10.1155/2021/6665697 |
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