Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway
Background. The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8291316 |
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| author | Orlei Ribeiro de Araujo Reinaldo Salomão Milena Karina Coló Brunialti Dafne Cardoso Bourguignon da Silva Andreza Almeida Senerchia Fabianne Altruda de Moraes Costa Carlesse Antonio Sergio Petrilli |
| author_facet | Orlei Ribeiro de Araujo Reinaldo Salomão Milena Karina Coló Brunialti Dafne Cardoso Bourguignon da Silva Andreza Almeida Senerchia Fabianne Altruda de Moraes Costa Carlesse Antonio Sergio Petrilli |
| author_sort | Orlei Ribeiro de Araujo |
| collection | DOAJ |
| description | Background. The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis. Methods. IL-1β, TNF-α, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients. Results. Thirteen patients (37.1%) developed sepsis. In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P<0.005), and IL-12/23p40 and IL-17 in nonseptic patients (P<0.05). On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim. Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis. Associating the markers with each other or to a risk assessment model improved performance. Conclusions. Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis. |
| format | Article |
| id | doaj-art-4763790505d545bebc9c014dc2b32ae0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4763790505d545bebc9c014dc2b32ae02025-02-03T06:00:03ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/82913168291316Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 PathwayOrlei Ribeiro de Araujo0Reinaldo Salomão1Milena Karina Coló Brunialti2Dafne Cardoso Bourguignon da Silva3Andreza Almeida Senerchia4Fabianne Altruda de Moraes Costa Carlesse5Antonio Sergio Petrilli6Grupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, BrazilDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 669, 10th Floor, 04039-001 São Paulo, SP, BrazilDivision of Infectious Diseases, Department of Medicine, Escola Paulista de Medicina, Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 669, 10th Floor, 04039-001 São Paulo, SP, BrazilGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, BrazilGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, BrazilGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, BrazilGrupo de Apoio ao Adolescente e à Criança com Câncer (GRAACC), Instituto de Oncologia Pediatrica (IOP), Sao Paulo Federal University (UNIFESP), Rua Pedro de Toledo 572-Vila Clementino, 04039-001 São Paulo, SP, BrazilBackground. The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis. Methods. IL-1β, TNF-α, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients. Results. Thirteen patients (37.1%) developed sepsis. In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P<0.005), and IL-12/23p40 and IL-17 in nonseptic patients (P<0.05). On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim. Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis. Associating the markers with each other or to a risk assessment model improved performance. Conclusions. Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.http://dx.doi.org/10.1155/2017/8291316 |
| spellingShingle | Orlei Ribeiro de Araujo Reinaldo Salomão Milena Karina Coló Brunialti Dafne Cardoso Bourguignon da Silva Andreza Almeida Senerchia Fabianne Altruda de Moraes Costa Carlesse Antonio Sergio Petrilli Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway Mediators of Inflammation |
| title | Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway |
| title_full | Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway |
| title_fullStr | Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway |
| title_full_unstemmed | Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway |
| title_short | Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway |
| title_sort | cytokine kinetics in febrile neutropenic children insights on the usefulness as sepsis biomarkers influence of filgrastim and behavior of the il 23 il 17 pathway |
| url | http://dx.doi.org/10.1155/2017/8291316 |
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